期刊
POLYCYCLIC AROMATIC COMPOUNDS
卷 43, 期 8, 页码 7223-7237出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/10406638.2022.2131852
关键词
Diisopropyl ethyl ammonium acetate; multicomponent reaction; green synthesis; amino pyrazole derivatives
A green synthesis method has been developed to efficiently access pharmaceutically relevant functionalized coumarin-pyrazole molecular hybrids. This new procedure offers high yields, short reaction times, simple experimental and work-up procedures, mild reaction conditions and environmental friendliness, along with an economically available catalyst.
Development of a green protocol to access pharmaceutically relevant functionalized coumarin-pyrazole molecular hybrids, dihydrochromeno[4,3-b]Pyrazolo[4,3-e]pyridin-6(7H)-ones, has been accomplished based on a three-component tandem reaction between aromatic aldehydes, 4-hydroxycoumarin and 3-aminopyrazoles in presence of Diisopropyl Ethyl Ammonium Acetate (DIPEAc) as catalyst and solvent at room temperature is reported. The remarkable features of this new procedure are high yields, short reaction times, simple experimental and work-up procedures, mild and environmentally friendly reaction conditions, and the economic availability of the catalyst.
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