期刊
PLOS ONE
卷 17, 期 9, 页码 -出版社
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0272587
关键词
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资金
- Biotechnology and Biological Sciences Research Council [BB/L023776/1, BB/M011178/1]
- Cancer Research UK [C36195/A26770, C36195/A27830]
- Blood Cancer UK [15040]
- Wellcome Trust [212304/Z/18/Z]
- Wellcome Trust [212304/Z/18/Z] Funding Source: Wellcome Trust
Multi-potent progenitor cells play a key role in hematopoiesis by migrating in and out of different niches to determine their fate. Our analysis of experimental data and the use of a cell motion model revealed that these cells display transient super-diffusion, highlighting the importance of motility in early hematopoietic progenitor function.
Multi-potent progenitor (MPP) cells act as a key intermediary step between haematopoietic stem cells and the entirety of the mature blood cell system. Their eventual fate determination is thought to be achieved through migration in and out of spatially distinct niches. Here we first analyze statistically MPP cell trajectory data obtained from a series of long time-course 3D in vivo imaging experiments on irradiated mouse calvaria, and report that MPPs display transient super-diffusion with apparent non-Gaussian displacement distributions. Second, we explain these experimental findings using a run-and-tumble model of cell motion which incorporates the observed dynamical heterogeneity of the MPPs. Third, we use our model to extrapolate the dynamics to time-periods currently inaccessible experimentally, which enables us to quantitatively estimate the time and length scales at which super-diffusion transitions to Fickian diffusion. Our work sheds light on the potential importance of motility in early haematopoietic progenitor function.
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