4.7 Article

Polydatin prevents lipotoxicity-induced dysfunction in pancreatic β-cells by inhibiting endoplasmic reticulum stress and excessive autophagy

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Pharmacology & Pharmacy

Obesity and insulin resistance: Pathophysiology and treatment

Yue Tong et al.

Summary: The prevalence of obesity is a major cause of chronic metabolic disorders. This review discusses the mechanisms of insulin resistance and current therapeutic strategies for obesity.

DRUG DISCOVERY TODAY (2022)

Article Medicine, Research & Experimental

Polydatin mitigates pancreatic β-cell damage through its antioxidant activity

Ahmed I. Yousef et al.

Summary: Research has shown that polydatin has protective effects on diabetic rats and pancreatic beta-cells, enhancing insulin secretion and improving lipid metabolism, while reducing oxidative damage.

BIOMEDICINE & PHARMACOTHERAPY (2021)

Review Biochemistry & Molecular Biology

Deficient Leptin Cellular Signaling Plays a Key Role in Brain Ultrastructural Remodeling in Obesity and Type 2 Diabetes Mellitus

Melvin R. Hayden et al.

Summary: Obesity, metabolic syndrome, type 2 diabetes, and aging are global societal problems with potential complications, causing economic burdens to individuals and families. This review focuses on the role of leptin hormone from white adipose tissue in brain remodeling in female mice with hyperphagia, obesity, or hyperglycemia, examining structural changes in various brain components.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Oncology

Polydatin Reduces Cardiotoxicity and Enhances the Anticancer Effects of Sunitinib by Decreasing Pro-Oxidative Stress, Pro-Inflammatory Cytokines, and NLRP3 Inflammasome Expression

Vincenzo Quagliariello et al.

Summary: Polydatin has potential cardioprotective and chemosensitizing effects during Sunitinib treatment by reducing oxidative stress and key chemokines related to cancer cell survival and chemoresistance. Through modulation of inflammatory responses and signaling pathways, it can act as a nutraceutical agent in preventive cardio-oncology studies.

FRONTIERS IN ONCOLOGY (2021)

Review Endocrinology & Metabolism

Inadequate beta-cell mass is essential for the pathogenesis of type 2 diabetes

Gordon C. Weir et al.

LANCET DIABETES & ENDOCRINOLOGY (2020)

Review Endocrinology & Metabolism

Pancreatic β-cells in type 1 and type 2 diabetes mellitus: different pathways to failure

Decio L. Eizirik et al.

NATURE REVIEWS ENDOCRINOLOGY (2020)

Review Pharmacology & Pharmacy

Molecular imaging of β-cells: diabetes and beyond

Weijun Wei et al.

ADVANCED DRUG DELIVERY REVIEWS (2019)

Article Biochemistry & Molecular Biology

Autophagy in Adipose Tissue Physiology and Pathophysiology

Maroua Ferhat et al.

ANTIOXIDANTS & REDOX SIGNALING (2019)

Article Cell Biology

Type 2 diabetes is associated with suppression of autophagy and lipid accumulation in β-cells

Jeff Ji et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2019)

Article Biotechnology & Applied Microbiology

Polydatin Inhibits Adipose Tissue Inflammation and Ameliorates Lipid Metabolism in High-Fat-Fed Mice

Li Zheng et al.

BIOMED RESEARCH INTERNATIONAL (2019)

Article Biochemistry & Molecular Biology

Sphingosine kinase 2 promotes lipotoxicity in pancreatic -cells and the progression of diabetes

Ziyu Song et al.

FASEB JOURNAL (2019)

Article Biochemistry & Molecular Biology

Functional proteasome complex is required for turnover of islet amyloid polypeptide in pancreatic -cells

Diti Chatterjee Bhowmick et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2018)

Article Biochemistry & Molecular Biology

Inhibition of p38 mitogen-activated protein kinase exerts a hypoglycemic effect by improving β cell function via inhibition of β cell apoptosis in db/db mice

Xiaowei Wei et al.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2018)

Article Chemistry, Medicinal

Discovery of a Benzamide Derivative That Protects Pancreatic β-Cells against Endoplasmic Reticulum Stress

Hongliang Duan et al.

JOURNAL OF MEDICINAL CHEMISTRY (2017)

Article Multidisciplinary Sciences

Loss of mTORC1 signalling impairs β-cell homeostasis and insulin processing

Manuel Blandino-Rosano et al.

NATURE COMMUNICATIONS (2017)

Article Pathology

Multiple Mechanisms of Unfolded Protein Response-Induced Cell Death

Nobuhiko Hiramatsu et al.

AMERICAN JOURNAL OF PATHOLOGY (2015)

Review Cell Biology

ER stress: Autophagy induction, inhibition and selection

Harun-Or Rashid et al.

AUTOPHAGY (2015)

Article Biochemistry & Molecular Biology

Sphingosine Kinase 1 Protects Hepatocytes from Lipotoxicity via Down-regulation of IRE1α Protein Expression

Yanfei Qi et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2015)

Review Biochemistry & Molecular Biology

Proinsulin misfolding and endoplasmic reticulum stress during the development and progression of diabetes

Jinhong Sun et al.

MOLECULAR ASPECTS OF MEDICINE (2015)

Review Endocrinology & Metabolism

Lipotoxic endoplasmic reticulum stress, β cell failure, and type 2 diabetes mellitus

Trevor J. Biden et al.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2014)

Review Plant Sciences

Autophagy as initiator or executioner of cell death

Elena A. Minina et al.

TRENDS IN PLANT SCIENCE (2014)

Review Biochemistry & Molecular Biology

Endoplasmic Reticulum Stress and Type 2 Diabetes

Sung Hoon Back et al.

ANNUAL REVIEW OF BIOCHEMISTRY, VOL 81 (2012)

Article Endocrinology & Metabolism

HDLs Protect Pancreatic β-Cells Against ER Stress by Restoring Protein Folding and Trafficking

Jannick Petremand et al.

DIABETES (2012)

Article Biochemistry & Molecular Biology

Regulation of glucose homeostasis through a XBP-1-FoxO1 interaction

Yingjiang Zhou et al.

NATURE MEDICINE (2011)

Review Multidisciplinary Sciences

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

Peter Walter et al.

SCIENCE (2011)

Review Cell Biology

Regulation of basal cellular physiology by the homeostatic unfolded protein response

D. Thomas Rutkowski et al.

JOURNAL OF CELL BIOLOGY (2010)

Review Cell Biology

Initiation and execution of lipotoxic ER stress in pancreatic β-cells

Daniel A. Cunha et al.

JOURNAL OF CELL SCIENCE (2008)

Article Endocrinology & Metabolism

The endoplasmic reticulum in pancreatic beta cells of type 2 diabetes patients

P. Marchetti et al.

DIABETOLOGIA (2007)

Review Cell Biology

Signal integration in the endoplasmic reticulum unfolded protein response

David Ron et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)

Article Endocrinology & Metabolism

Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes

D. R. Laybutt et al.

DIABETOLOGIA (2007)