Perillyl alcohol attenuates chronic restraint stress aggravated dextran sulfate sodium-induced ulcerative colitis by modulating TLR4/NF-κB and JAK2/STAT3 signaling pathways

Article Immunology

Perillyl alcohol inhibits keratinocyte proliferation and attenuates imiquimod-induced psoriasis like skin-inflammation by modulating NF-?B and STAT3 signaling pathways

Md. Abubakar et al.

Summary: Perillyl alcohol (POH) exhibits potential therapeutic effects on psoriasis by reducing inflammation and proliferative markers, showing significant results in vitro and in animal models.

INTERNATIONAL IMMUNOPHARMACOLOGY (2022)

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Article Biochemistry & Molecular Biology

Sesamol ameliorates dextran sulfate sodium-induced depression-like and anxiety-like behaviors in colitis mice: the potential involvement of the gut-brain axis

Bing Xia et al.

Summary: The study found that sesamol prevented inflammatory response, epithelial barrier dysfunction, and depression-like and anxiety-like behaviors in mice with DSS-induced IBD. Sesamol achieved this protective effect by suppressing neuroinflammatory responses, protecting against oxidative stress, improving BDNF levels, and restoring synaptic impairments. The gut barrier and LPS content were found to be highly associated with behavioral performance and brain biochemical indexes.

FOOD & FUNCTION (2022)

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Article Materials Science, Biomaterials

Multifunctional Polymeric Nanoparticles for Chemo/Phototheranostics of Retinoblastoma

Sushma Venkata Mudigunda et al.

Summary: Retinoblastoma is a critical intraocular malignancy in children, and chemo/photothermal therapy with multifunctional polymeric nanoparticles (PNPs) entrapped with anticancer drug and near-infrared dye showed significant cytotoxic effect on retinoblastoma cells. In vivo studies in a mice model demonstrated optimal photoacoustic signals, suggesting the potential of this combined approach for retinoblastoma therapy.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2022)

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Article Plant Sciences

Perillyl alcohol attenuates rheumatoid arthritis via regulating TLR4/NF-κB and Keap1/Nrf2 signaling pathways: A comprehensive study onin-vitro and in-vivo experimental models

Eswara Rao Puppala et al.

Summary: This study aimed to evaluate the anti-inflammatory effects of perillyl alcohol (POH) on rheumatoid arthritis. The results demonstrated that POH suppressed inflammation and oxidative stress through regulating signaling pathways in both in vitro and in vivo experiments. These findings suggest the potential therapeutic effects of POH in rheumatoid arthritis.

PHYTOMEDICINE (2022)

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Article Plant Sciences

Astragaloside IV alleviates ulcerative colitis by regulating the balance of Th17/Treg cells

Youbao Zhong et al.

Summary: AS-IV effectively prevents and alleviates ulcerative colitis by reshaping Th17/Treg cell homeostasis and anti-oxidative stress.

PHYTOMEDICINE (2022)

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Article Immunology

HPA axis regulation and epigenetic programming of immune-related genes in chronically stressed and non-stressed mid-life women

Helena Palma-Gudiel et al.

Summary: The study identified an association between chronic stress and HPA axis regulation with epigenetic signatures at immune-related genes, indicating how aberrant HPA axis function may contribute to heightened inflammation and disease risk.

BRAIN BEHAVIOR AND IMMUNITY (2021)

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Article Medicine, Research & Experimental

A novel bioavailable curcumin-galactomannan complex modulates the genes responsible for the development of chronic diseases in mice: A RNA sequence analysis

Kishore Banik et al.

Summary: The novel curcumagalactomannosides (CGM) have shown higher bioavailability than traditional curcumin, indicating potential for prevention and treatment of chronic diseases. The study revealed significant effects of CGM on the expression of various genes in liver tissues, suggesting its therapeutic benefits for multiple chronic diseases.

LIFE SCIENCES (2021)

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Article Chemistry, Multidisciplinary

Geometry encoded functional programming of tumor homing peptides for targeted drug delivery

Ruchika Goyal et al.

Summary: The research demonstrates that designed and optimized peptides have different uptake abilities in various cancer cells and can penetrate tumorospheres. The cytotoxic effects of these peptides were confirmed to be apoptotic by observing mitochondrial membrane potential depolarization and Caspase-3 activation. Additionally, in vivo and clinical samples studies further confirmed the peptides' ability to selectively recognize tumor cells.

JOURNAL OF CONTROLLED RELEASE (2021)

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Article Pharmacology & Pharmacy

Polyphenolic-Rich Compounds From Dillenia pentagyna (Roxb.) Attenuates the Doxorubicin-Induced Cardiotoxicity: A High-Frequency Ultrasonography Assisted Approach

Kalyani Tene et al.

Summary: The extract of DP showed strong antioxidant potential in combating Dox-induced cardiotoxicity, protecting cardiomyocytes and reducing ROS levels, which could be attributed to polyphenolic antioxidant compounds present in DP such as gallic acid, syringic acid, and sinapic acid.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Pharmacology & Pharmacy

Lithocholic acid-tryptophan conjugate (UniPR126) based mixed micelle as a nano carrier for specific delivery of niclosamide to prostate cancer via EphA2 receptor

Arun Kumar Jannu et al.

Summary: Targeted delivery of chemotherapeutic agent through EphA2 receptor using UniPR126 as a carrier in mixed nanomicellar system showed significant enhancement in uptake by cancer cells and resulted in synergistic cytotoxicity. In vivo data also revealed a reduction in tumor volume with niclosamide-loaded nanomicelle compared to pure niclosamide, indicating improved anticancer efficacy through interference with EphA2 receptor signaling and inhibition of the Wnt/beta-catenin pathway.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

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Review Neurosciences