Tanshinone I inhibits doxorubicin-induced cardiotoxicity by regulating Nrf2 signaling pathway

Article Plant Sciences

Apocynum venetum leaf extract alleviated doxorubicin-induced cardiotoxicity through the AKT/Bcl-2 signaling pathway

Yang Zhang et al.

Summary: Apocynum venetum L. leaf extract alleviates doxorubicin-induced cardiomyocyte apoptosis by suppressing oxidative stress and apoptosis through the AKT/Bcl-2 signaling pathway.

PHYTOMEDICINE (2022)

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Review Pharmacology & Pharmacy

Role of Nrf2 Signaling Cascade in Breast Cancer: Strategies and Treatment

Hitesh Kumar et al.

Summary: This article discusses the role of Nrf2 in the development of drug resistance, angiogenesis, cancer stem cell generation, and metastasis in breast cancer. Therapeutic strategies utilizing Nrf2 signaling cascades are also discussed.

FRONTIERS IN PHARMACOLOGY (2022)

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Article Cardiac & Cardiovascular Systems

Anthracycline-free tumor elimination in mice leads to functional and molecular cardiac recovery from cancer-induced alterations in contrast to long-lasting doxorubicin treatment effects

Stefan Pietzsch et al.

Summary: Research indicates that the heart can recover from cancer-induced damage after chemotherapy-free tumor elimination, whereas treatment with the cardiotoxic drug Doxorubicin may result in long-term subclinical changes in the heart, particularly affecting circadian clock genes. These changes could potentially render the heart more sensitive to additional stress during lifetime, contributing to late cardiac toxicity.

BASIC RESEARCH IN CARDIOLOGY (2021)

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Article Biochemistry & Molecular Biology

Songorine promotes cardiac mitochondrial biogenesis via Nrf2 induction during sepsis

Yi Li et al.

Summary: Songorine protects cardiac contractive function against endotoxin insult by activating Nrf2, suppressing mitochondrial reactive oxygen species production, and promoting mitochondrial biogenesis, ultimately enhancing cardioprotection.

REDOX BIOLOGY (2021)

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Review Biochemistry & Molecular Biology

Nrf2 Signaling Pathway in Chemoprotection and Doxorubicin Resistance: Potential Application in Drug Discovery

Sepideh Mirzaei et al.

Summary: Doxorubicin (DOX) is commonly used in cancer therapy for its efficacy, but its dose-dependent toxicity has led to the study of mechanisms underlying DOX resistance, with a focus on the importance of Nrf2 signaling in alleviating its adverse effects.

ANTIOXIDANTS (2021)

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Article Medicine, Research & Experimental

Tanshinone I and Tanshinone IIA/B attenuate LPS-induced mastitis via regulating the NF-κB

Lili Yang et al.

Summary: Tanshinone I and Tanshinone IIA/B demonstrated potential in treating mastitis by reducing inflammation and regulating NF-kappa B activation. Clinical trials showed better outcomes with the combined treatment of Cefprozil and Tanshinone compared to Cefprozil alone. Animal and cell studies further supported the beneficial effects of Tanshinones in treating mastitis.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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Article Biochemistry & Molecular Biology

Irisin ameliorates doxorubicin-induced cardiac perivascular fibrosis through inhibiting endothelial-to-mesenchymal transition by regulating ROS accumulation and autophagy disorder in endothelial cells

Jian-An Pan et al.

Summary: The study revealed the protective role of irisin in EndMT and perivascular fibrosis in the cardiac microenvironment in a mouse DIC model, potentially reversing ROS accumulation and autophagy disorders by regulating UCP2. Irisin was found to be mainly secreted by cardiomyocytes and had a paracrine protective effect on endothelial cells. This study provides a novel perspective on the pathogenesis and potential treatment of DIC.

REDOX BIOLOGY (2021)

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Article Biochemistry & Molecular Biology

Epigallocatechin-3-gallate pretreatment alleviates doxorubicin-induced ferroptosis and cardiotoxicity by upregulating AMPKα2 and activating adaptive autophagy

Huan He et al.

Summary: The mechanism of Doxorubicin-induced cardiotoxicity is complex, involving multiple cell death forms, with clinical intervention effect not ideal. By inhibiting iron accumulation, oxidative stress, and abnormal lipid metabolism, it is possible to alleviate Doxorubicin-induced cardiotoxicity-induced ferroptosis and protect the myocardium. Epigallocatechin-3-gallate is a potential candidate phytochemical for combating Doxorubicin-induced cardiotoxicity.

REDOX BIOLOGY (2021)

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Review Biochemistry & Molecular Biology

Role of Oxidative Stress in Heart Failure: Insights from Gene Transfer Studies

Bart De Geest et al.

Summary: Oxidative stress plays a key pathophysiological role in the development of heart failure, with gene therapy studies providing evidence of its role in pathological remodeling. Mitochondria serve as the main source of ROS in the myocardium, and redox-sensitive microRNAs are potential therapeutic targets for heart failure treatment.

BIOMEDICINES (2021)

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Article Medicine, Research & Experimental

Resveratrol significantly improves cell survival in comparison to dexrazoxane and carvedilol in a h9c2 model of doxorubicin induced cardiotoxicity

David S. Monahan et al.

Summary: Cancer causes 18.1 million deaths per year globally, with anti-cancer therapies often leading to severe side effects. Dexrazoxane is currently the only approved treatment for preventing anthracycline-induced cardiotoxicity, but resveratrol may be more effective in prevention. Further research is needed to understand the mechanisms and potential of resveratrol in clinical settings.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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Article Medicine, Research & Experimental

Hesperetin modulates the Sirt1/Nrf2 signaling pathway in counteracting myocardial ischemia through suppression of oxidative stress, inflammation, and apoptosis

Panpan Liu et al.

Summary: This study found that Hesperetin has a protective effect on ISO-induced myocardial ischemia in mice, possibly by modulating oxidative stress, inflammation, and apoptosis pathways.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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Article Multidisciplinary Sciences

Activation of Nrf2/HO-1 signaling: An important molecular mechanism of herbal medicine in the treatment of atherosclerosis via the protection of vascular endothelial cells from oxidative stress

Qing Zhang et al.

Summary: This study summarized natural compounds that exert protective effects against oxidative stress in vascular endothelial cells (ECs), including phenylpropanoids, flavonoids, terpenoids, and alkaloids. These compounds alleviate EC apoptosis by activating the Nrf2/HO-1 signaling pathway, showing potential for the treatment of atherosclerosis.

JOURNAL OF ADVANCED RESEARCH (2021)

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Article Biochemistry & Molecular Biology

Nerolidol Attenuates Oxidative Stress, Inflammation, and Apoptosis by Modulating Nrf2/MAPK Signaling Pathways in Doxorubicin-Induced Acute Cardiotoxicity in Rats

Seenipandi Arunachalam et al.

Summary: This study investigated the cardioprotective effects of nerolidol in a rat model of doxorubicin-induced acute cardiotoxicity, highlighting its antioxidant, anti-inflammatory, and antiapoptotic activities through modulation of cellular signaling pathways.

ANTIOXIDANTS (2021)

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Article Medicine, Research & Experimental

Tanshinone I, a new EZH2 inhibitor restricts normal and malignant hematopoiesis through upregulation of MMP9 and ABCG2

Ying Huang et al.

Summary: The study confirmed Tanshinone I as a novel EZH2 inhibitor that regulates normal and malignant hematopoiesis, and identified MMP9 and ABCG2 as potential therapeutic targets for myeloid malignant diseases.

THERANOSTICS (2021)

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Article Medicine, Research & Experimental

Pulmonary circulation-mediated heart targeting for the prevention of heart failure by inhalation of intrinsically bioactive nanoparticles

Chao Liu et al.

Summary: This study demonstrated the use of inhalation delivery of nanotherapies for preventing heart failure. The synthesized ROS-scavenging material TPCD NP showed efficacy in reducing oxidative stress and cell injury. The engineered TTPCD NP exhibited enhanced therapeutic effects for heart targeting and cellular uptake.

THERANOSTICS (2021)

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Article Medicine, Research & Experimental