4.5 Review

An updated and comprehensive review on the ethnomedicinal uses, phytochemistry, pharmacological activity and toxicological profile of Tinospora crispa (L.) Hook. f. & Thomson

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Article Plant Sciences

Probing PXR activation and modulation of CYP3A4 by Tinospora crispa and Tinospora sinensis

Abidah Parveen et al.

Summary: In this study, the potential herb-drug interaction of Tinospora crispa and Tinospora sinensis was investigated by testing their extracts and compounds. The results indicate that these plants have the potential to mediate herb-drug interaction through PXR activation and inhibition of CYP3A4 isozyme.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

Article Chemistry, Applied

Rearranged clerodane diterpenoid from Tinospora crispa

Abidah Parveen et al.

Summary: A new rearranged clerodane diterpenoid, tinocrispide, was isolated from the stems of Tinospora crispa along with thirteen known compounds, including eight clerodane diterpenoids. Among the known compounds, baenzigeride A, (6S, 9 R)-vomifoliol, and steponine were reported for the first time from T. crispa. Structures were elucidated using 1D and 2D NMR and confirmed by HRESIMS. Additionally, the C-13 NMR data of borapetol A has been revised.

NATURAL PRODUCT RESEARCH (2021)

Article Engineering, Multidisciplinary

THE MOLLUSCICIDAL EFFECT OF THE STEM EXTRACTS OF Tinospora crispa IN CONTROLLING THE GOLDEN APPLE SNAIL Pomacea canaliculata

Noorshilawati Abdul Aziz et al.

Summary: This study investigated the molluscicidal effect of Tinospora crispa stem extracts on Pomacea canaliculata, finding that extracts prepared in methanol at 10,000 ppm showed the highest mortality rate of 80% at 72 h. Phytochemicals such as alkaloids, flavonoids, saponin, tannin, and terpenoids were identified in the extracts. Probit analysis revealed that the methanol extracts had the lowest LC50 value of 3,428 ppm for molluscicidal potential.

JURNAL TEKNOLOGI-SCIENCES & ENGINEERING (2021)

Review Food Science & Technology

The inhibitory effects of flavonoids on α-amylase and α-glucosidase

Jianzhong Zhu et al.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2020)

Article Pharmacology & Pharmacy

Phytochemical analysis and evaluation of purified extract of Tinospora crispa stem for in vivo antihyperuricemic effect

Harwoko Harwoko et al.

JOURNAL OF REPORTS IN PHARMACEUTICAL SCIENCES (2020)

Article Environmental Sciences

Efficiency of Tinospora crispa against Culex quinquefasciatus larva

Wannee Jiraungkoorskul

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2019)

Article Biochemistry & Molecular Biology

Evaluation of a flavonoids library for inhibition of pancreatic alpha-amylase towards a structure-activity relationship

Carina Proenca et al.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2019)

Article Integrative & Complementary Medicine

Susceptibility of Toxoplasma gondii to Ethanolic Extract of Tinospora crispa in Vero Cells

Alhassan Abdullahi Sharif et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2019)

Article Plant Sciences

Crispenes F and G, cis-Clerodane Furanoditerpenoids from Tinospora crispa, Inhibit STAT3 Dimerization

Md. Abdullah Al Noman et al.

JOURNAL OF NATURAL PRODUCTS (2018)

Review Chemistry, Medicinal

New Analogues of Aporphine Alkaloids

Yi-Chao Ge et al.

MINI-REVIEWS IN MEDICINAL CHEMISTRY (2018)

Article Integrative & Complementary Medicine

Antiprotozoal properties of Indonesian medicinal plant extracts

Arba P. Ramadani et al.

JOURNAL OF HERBAL MEDICINE (2018)

Article Multidisciplinary Sciences

Clerodane furanoditerpenoids as the probable cause of toxic hepatitis induced by Tinospora crispa

Xavier Cachet et al.

SCIENTIFIC REPORTS (2018)

Article Biochemistry & Molecular Biology

alpha-Glucosidase inhibition by flavonoids: an in vitro and in silico structure-activity relationship study

Carina Proenca et al.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2017)

Review Plant Sciences

Tinospora species: An overview of their modulating effects on the immune system

Md Areeful Haque et al.

JOURNAL OF ETHNOPHARMACOLOGY (2017)

Proceedings Paper Biochemistry & Molecular Biology

High perfomance liquid chromatography fingerprint analysis for quality control of brotowali (Tinospora crispa)

V. B. Syarifah et al.

INTERNATIONAL SYMPOSIUM ON BIOINFORMATICS, CHEMOMETRICS AND METABOLOMICS (2017)

Article Chemistry, Medicinal

Compounds Isolated from Tinospora crispa

Muhammad Ismail et al.

CHEMISTRY OF NATURAL COMPOUNDS (2016)

Review Integrative & Complementary Medicine

Genus Tinospora: Ethnopharmacology, Phytochemistry, and Pharmacology

Sensen Chi et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2016)

Article Chemistry, Medicinal

Crispene A, B, C and D, Four New Clerodane Type Furanoid Diterpenes from Tinospora crispa (L.)

Farhad Hossen et al.

PHARMACOGNOSY MAGAZINE (2016)

Review Chemistry, Medicinal

The Significance of Tinospora crispa in Treatment of Diabetes Mellitus

Alex Thomas et al.

PHYTOTHERAPY RESEARCH (2016)

Article Biochemistry & Molecular Biology

Standardized extract of Tinospora crispa stimulates innate and adaptive immune responses in Balb/c mice

Waqas Ahmad et al.

FOOD & FUNCTION (2016)

Article Chemistry, Medicinal

Clerodane Diterpenoids with Anti-hyperglycemic Activity from Tinospora crispa

Yuan Gao et al.

NATURAL PRODUCTS AND BIOPROSPECTING (2016)

Article Biochemistry & Molecular Biology

Acylated glucosylflavones as α-glucosidase inhibitors from Tinospora crispa leaf

Chi-Chih Chang et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2015)

Article Integrative & Complementary Medicine

Tinospora crispa Ameliorates Insulin Resistance Induced by High Fat Diet in Wistar Rats

Mohd Nazri Abu et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2015)

Article Chemistry, Organic

Crispene E, a cis-clerodane diterpene inhibits STAT3 dimerization in breast cancer cells

Julia Mantaj et al.

ORGANIC & BIOMOLECULAR CHEMISTRY (2015)

Article Integrative & Complementary Medicine

Immunomodulatory effect of an isolated fraction from Tinospora crispa on intracellular expression of INF-γ, IL-6 and IL-8

Walaa Najm Abood et al.

BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE (2014)

Article Biochemistry & Molecular Biology

Anticholinesterase Inhibitory Activity of Quaternary Alkaloids from Tinospora crispa

Mashitah Yusoff et al.

MOLECULES (2014)

Article Plant Sciences

Toxic hepatitis induced by a herbal medicine: Tinospora crispa

J. Langrand et al.

PHYTOMEDICINE (2014)

Article Integrative & Complementary Medicine

Antidiabetic Effect of Oral Borapetol B Compound, Isolated from the Plant Tinospora crispa, by Stimulating Insulin Release

Faradianna E. Lokman et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2013)

Review Pharmacology & Pharmacy

A Review of the Secondary Metabolites and Biological Activities of Tinospora crispa (Menispermaceae)

Yen Chin Koay et al.

TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH (2013)

Article Multidisciplinary Sciences

The effect of Tinospora crispa extract against Spodoptera exigua on Spinacia oleracea

Norain Isa et al.

MALAYSIAN JOURNAL OF FUNDAMENTAL AND APPLIED SCIENCES (2013)

Article Biotechnology & Applied Microbiology

The Effect of Tinospora crispa on Serum Glucose and Insulin Levels in Patients with Type 2 Diabetes Mellitus

Theerawut Klangjareonchai et al.

JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY (2012)

Article Plant Sciences

Hypoglycemic Diterpenoids from Tinospora crispa

Sio-Hong Lam et al.

JOURNAL OF NATURAL PRODUCTS (2012)

Article Microbiology

Antimicrobial activity of the aqueous extract of selected Malaysian herbs

Z. A. Zakaria et al.

AFRICAN JOURNAL OF MICROBIOLOGY RESEARCH (2011)

Article Pharmacology & Pharmacy

Effect of Tinospora crispa on thioacetamide-induced liver cirrhosis in rats

Farkaad A. Kadir et al.

INDIAN JOURNAL OF PHARMACOLOGY (2011)

Article Plant Sciences

Antituberculosis potential of some ethnobotanically selected Malaysian plants

Suriyati Mohamad et al.

JOURNAL OF ETHNOPHARMACOLOGY (2011)

Article Plant Sciences

cis-Clerodane-Type Furanoditerpenoids from Tinospora crispa

M. Iqbal Choudhary et al.

JOURNAL OF NATURAL PRODUCTS (2010)

Article Plant Sciences

Medicinal plant knowledge and its erosion among the Mien (Yao) in northern Thailand

Kamonnate Srithi et al.

JOURNAL OF ETHNOPHARMACOLOGY (2009)

Article Plant Sciences

Medicinal plants used by the villagers of a Sundanese community in West Java, Indonesia

Katrin Roosita et al.

JOURNAL OF ETHNOPHARMACOLOGY (2008)

Article Plant Sciences

Herbs for medicinal baths among the traditional Yao communities of China

Sumei Li et al.

JOURNAL OF ETHNOPHARMACOLOGY (2006)

Article Plant Sciences

Screening of selected indigenous plants of Cambodia for antiplasmodial activity

Sotheara Hout et al.

JOURNAL OF ETHNOPHARMACOLOGY (2006)

Article Plant Sciences

Mechanism-based inhibition of CYP3A4 and CYP2D6 by Indonesian medicinal plants

Subehan et al.

JOURNAL OF ETHNOPHARMACOLOGY (2006)

Article Nutrition & Dietetics

Inhibition of α-glucosidase and α-amylase by flavonoids

K Tadera et al.

JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY (2006)

Article Plant Sciences

Antimalarial remedies in French Guiana: A knowledge attitudes and practices study

M Vigneron et al.

JOURNAL OF ETHNOPHARMACOLOGY (2005)

Article Plant Sciences

Evaluation of french Guiana traditional antimalarial remedies

S Bertani et al.

JOURNAL OF ETHNOPHARMACOLOGY (2005)

Review Plant Sciences

Plants with central analgesic activity

RN Almeida et al.

PHYTOMEDICINE (2001)