期刊
PHYTOCHEMISTRY
卷 203, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2022.113339
关键词
Ganoderma lucidum; Ganodermataceae; Triterpenoids; Lanostane; FAAH; Cytotoxicity
资金
- National Natural Science Foundation of China [81960703, 81560632]
- Natural Science Foundation of Liaoning Province [2021-MS-283]
- China Postdoctoral Science Foundation [2022MD713720]
- Dalian Young Star of Science and Technology [2021RQ013]
- Foundation of the Jiangxi Provincial Department of Science and Technology Youth Project [20202BABL216073]
- Natural Science Foundation for Academic and Technical Leaders of Jiangxi Province [20212BCJ23026]
- Project of the Health and Family Planning Commission of Jiangxi Province [202130182]
- Scientific Research Project of Traditional Chinese Medicine in Jiangxi Province [2020A0346]
This study investigated the bioactive phytochemicals in Ganoderma lucidum and found that its triterpenoids showed inhibitory effects on the enzyme FAAH, indicating their potential for treating neuroinflammation.
Ganoderma lucidum is a famous edible and medicinal fungus. Through a bioactive phytochemical investigation of the ethanolic extracts of the fruiting bodies of G. lucidum, twenty-nine triterpenoids, including eleven previously undescribed triterpenoids, were isolated and characterized based on spectroscopic data. The inhibitory effects of all the triterpenes against fatty acid amide hydrolase (FAAH) were found to be in the range of 30-60% at 100 mu M. Methyl ganoderate A displayed the strongest inhibitory activity (61%) against FAAH. Furthermore, all com-pounds displayed no cytotoxicity against LOVO and MCF-7 human cancer cells. Hence, our present study pro-vides information about G. lucidum as a functional food or pharmaceutical supplement for the treatment of neuroinflammation.
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