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Matthew K. H. Hong et al.
NATURE COMMUNICATIONS (2015)
Lymphatic dysfunction attenuates tumor immunity through impaired antigen presentation
Takayuki Kimura et al.
ONCOTARGET (2015)
cKit Lineage Hemogenic Endothelium-Derived Cells Contribute to Mesenteric Lymphatic Vessels
Lukas Stanczuk et al.
CELL REPORTS (2015)
Investigation of the Lack of Angiogenesis in the Formation of Lymph Node Metastases
Han-Sin Jeong et al.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2015)
Vascular Endothelial Growth Factor-C Expression as a Biomarker of Poor Prognosis in Esophageal Squamous Cell Carcinoma: A Meta-Analysis
Thawatchai Tullavardhana et al.
ONCOLOGY RESEARCH AND TREATMENT (2015)
Blockade of VEGF-C and VEGF-D modulates adipose tissue inflammation and improves metabolic parameters under high-fat diet
Sinem Karaman et al.
MOLECULAR METABOLISM (2015)
How leukocytes cross the vascular endothelium
Dietmar Vestweber
NATURE REVIEWS IMMUNOLOGY (2015)
Targeting the tumor-draining lymph node with adjuvanted nanoparticles reshapes the anti-tumor immune response
Susan N. Thomas et al.
BIOMATERIALS (2014)
Blood microvessel density, lymphatic microvessel density and lymphatic invasion in predicting melanoma metastases: systematic review and meta-analysis
I. Pastushenko et al.
BRITISH JOURNAL OF DERMATOLOGY (2014)
Dissecting the Tumor Myeloid Compartment Reveals Rare Activating Antigen-Presenting Cells Critical for T Cell Immunity
Miranda L. Broz et al.
CANCER CELL (2014)
Restoration of natural killer cell cytotoxicity by VEGFR-3 inhibition in myelogenous leukemia
Ji Yoon Lee et al.
CANCER LETTERS (2014)
VEGF-C in non-small cell lung cancer: Meta-analysis
Hao Jiang et al.
CLINICA CHIMICA ACTA (2014)
Angiopoietin 2 regulates the transformation and integrity of lymphatic endothelial cell junctions
Wei Zheng et al.
GENES & DEVELOPMENT (2014)
Intratumoral vessel density as prognostic factors in head and neck squamous cell carcinoma: A meta- analysis of literature
Min Yu et al.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK (2014)
Activation of Vascular Endothelial Growth Factor Receptor-3 in Macrophages Restrains TLR4-NF-κB Signaling and Protects against Endotoxin Shock
Yanbo Zhang et al.
IMMUNITY (2014)
Prostanoid induces premetastatic niche in regional lymph nodes
Fumihiro Ogawa et al.
JOURNAL OF CLINICAL INVESTIGATION (2014)
Cyclooxygenase-2-dependent lymphangiogenesis promotes nodal metastasis of postpartum breast cancer
Traci R. Lyons et al.
JOURNAL OF CLINICAL INVESTIGATION (2014)
Nano-chemotherapeutics: Maximising lymphatic drug exposure to improve the treatment of lymph-metastatic cancers
Gemma M. Ryan et al.
JOURNAL OF CONTROLLED RELEASE (2014)
Lymph node stromal cells acquire peptide-MHCII complexes from dendritic cells and induce antigen-specific CD4+ T cell tolerance
Juan Dubrot et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2014)
Steady-State Antigen Scavenging, Cross-Presentation, and CD8+ T Cell Priming: A New Role for Lymphatic Endothelial Cells
Sachiko Hirosue et al.
JOURNAL OF IMMUNOLOGY (2014)
The effect of interstitial pressure on therapeutic agent transport: Coupling with the tumor blood and lymphatic vascular systems
Min Wu et al.
JOURNAL OF THEORETICAL BIOLOGY (2014)
Structure-based programming of lymph-node targeting in molecular vaccines
Haipeng Liu et al.
NATURE (2014)
The atypical chemokine receptor CCRL1 shapes functional CCL21 gradients in lymph nodes
Maria H. Ulvmar et al.
NATURE IMMUNOLOGY (2014)
Lymph Transport in Rat Mesenteric Lymphatics Experiencing Edemagenic Stress
Elaheh Rahbar et al.
MICROCIRCULATION (2014)
Tolerogenic Properties of Lymphatic Endothelial Cells Are Controlled by the Lymph Node Microenvironment
Jarish N. Cohen et al.
PLOS ONE (2014)
VEGF-D-induced draining lymphatic enlargement and tumor lymphangiogenesis promote lymph node metastasis in a xenograft model of ovarian carcinoma
Li-Cheng Du et al.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY (2014)
Bioengineering Dermo-Epidermal Skin Grafts with Blood and Lymphatic Capillaries
Daniela Marino et al.
SCIENCE TRANSLATIONAL MEDICINE (2014)
Taking the lymphatic route: dendritic cell migration to draining lymph nodes
Alvaro Teijeira et al.
SEMINARS IN IMMUNOPATHOLOGY (2014)
VEGF-C expression is associated with the poor survival in gastric cancer tissue
Weiguo Cao et al.
TUMOR BIOLOGY (2014)
Prognostic significance of VEGF-C immunohistochemical expression in breast cancer: a meta-analysis
Sheng Gao et al.
TUMOR BIOLOGY (2014)
Inflammatory cytokines induce vascular endothelial growth factor-C expression in melanoma-associated macrophages and stimulate melanoma lymph node metastasis
Silvia Peppicelli et al.
ONCOLOGY LETTERS (2014)
Breast cancer cells condition lymphatic endothelial cells within pre-metastatic niches to promote metastasis
Esak Lee et al.
NATURE COMMUNICATIONS (2014)
TNFR1 mediates TNF-α-induced tumour lymphangiogenesis and metastasis by modulating VEGF-C-VEGFR3 signalling
Hong Ji et al.
NATURE COMMUNICATIONS (2014)
Novel peptides suppress VEGFR-3 activity and antagonize VEGFR-3-mediated oncogenic effects
Yi-Wen Chang et al.
ONCOTARGET (2014)
Enhancing Efficacy of Anticancer Vaccines by Targeted Delivery to Tumor-Draining Lymph Nodes
Laura Jeanbart et al.
CANCER IMMUNOLOGY RESEARCH (2014)
Specific Inhibition of the VEGFR-3 Tyrosine Kinase by SAR131675 Reduces Peripheral and Tumor Associated Immunosuppressive Myeloid Cells
Nicolas Espagnolle et al.
CANCERS (2014)
The expression of vascular endothelial growth factor-C correlates with lymphatic microvessel density and lymph node metastasis in prostate carcinoma: An immunohistochemical study
Gyftopoulos Kostis et al.
UROLOGY ANNALS (2014)
A first-in-human phase I study of VGX-100, a selective anti-VEGF-C antibody, alone and in combination with bevacizumab in patients with advanced solid tumors
Gerald Steven Falchook et al.
JOURNAL OF CLINICAL ONCOLOGY (2014)
Lymphangiogenesis and lymphatic vessel remodelling in cancer
Steven A. Stacker et al.
NATURE REVIEWS CANCER (2014)
Use of a PEG-conjugated bright near-infrared dye for functional imaging of rerouting of tumor lymphatic drainage after sentinel lymph node metastasis
Steven T. Proulx et al.
BIOMATERIALS (2013)
Evidence for the interaction of fibroblast growth factor-2 with the lymphatic endothelial cell marker LYVE-1
Natalia Platonova et al.
BLOOD (2013)
VEGF-C and VEGF-D Blockade Inhibits Inflammatory Skin Carcinogenesis
Annamari K. Alitalo et al.
CANCER RESEARCH (2013)
Signaling for lymphangiogenesis via VEGFR-3 is required for the early events of metastasis
Masataka Matsumoto et al.
CLINICAL & EXPERIMENTAL METASTASIS (2013)
Adrenomedullin gene dosage correlates with tumor and lymph node lymphangiogenesis
Natalie O. Karpinich et al.
FASEB JOURNAL (2013)
Multifunctional nanoparticles co-delivering Trp2 peptide and CpG adjuvant induce potent cytotoxic T-lymphocyte response against melanoma and its lung metastasis
Zhenghong Xu et al.
JOURNAL OF CONTROLLED RELEASE (2013)
Vascular Endothelial Growth Factor-d Modulates Caliber and Function of Initial Lymphatics in the Dermis
Sophie Paquet-Fifield et al.
JOURNAL OF INVESTIGATIVE DERMATOLOGY (2013)
Inhibition of VEGF-C Modulates Distal Lymphatic Remodeling and Secondary Metastasis
Alvin Gogineni et al.
PLOS ONE (2013)
Vascular Endothelial Growth Factor Receptor-2 Promotes the Development of the Lymphatic Vasculature
Michael T. Dellinger et al.
PLOS ONE (2013)
Structural and mechanistic insights into VEGF receptor 3 ligand binding and activation
Veli-Matti Leppanen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Interstitial Dendritic Cell Guidance by Haptotactic Chemokine Gradients
Michele Weber et al.
SCIENCE (2013)
Insulin-like growth factor-1 induces lymphangiogenesis and facilitates lymphatic metastasis in colorectal cancer
Zhen-Jun Li et al.
WORLD JOURNAL OF GASTROENTEROLOGY (2013)
Initial afferent lymphatic vessels controlling outbound leukocyte traffic from skin to lymph noces
Alvaro Teijeira et al.
FRONTIERS IN IMMUNOLOGY (2013)
EphrinB2-EphB4 Signals Regulate Formation and Maintenance of Funnel-Shaped Valves in Corneal Lymphatic Capillaries
Hideto Katsuta et al.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2013)
A meta-analysis of the relationship between lymphatic microvessel density and clinicopathological parameters in breast cancer
Yigang Chen et al.
BULLETIN DU CANCER (2013)
Plasticity of Button-Like Junctions in the Endothelium of Airway Lymphatics in Development and Inflammation
Li-Chin Yao et al.
AMERICAN JOURNAL OF PATHOLOGY (2012)
DNA methylation regulates lineage-specifying genes in primary lymphatic and blood endothelial cells
Simone Broenneke et al.
ANGIOGENESIS (2012)
Differential requirement for ROCK in dendritic cell migration within lymphatic capillaries in steady-state and inflammation
Maximilian Nitschke et al.
BLOOD (2012)
VEGFR-3 is expressed on megakaryocyte precursors in the murine bone marrow and plays a regulatory role in megakaryopoiesis
Wilko Thiele et al.
BLOOD (2012)
Lymphatic endothelial cells induce tolerance via PD-L1 and lack of costimulation leading to high-level PD-1 expression on CD8 T cells
Eric F. Tewalt et al.
BLOOD (2012)
EphB4 promotes or suppresses Ras/MEK/ERK pathway in a context-dependent manner Implications for EphB4 as a cancer target
Zhan Xiao et al.
CANCER BIOLOGY & THERAPY (2012)
VEGF-D Promotes Tumor Metastasis by Regulating Prostaglandins Produced by the Collecting Lymphatic Endothelium
Tara Karnezis et al.
CANCER CELL (2012)
Interstitial Fluid Pressure and Associated Lymph Node Metastasis Revealed in Tumors by Dynamic Contrast-Enhanced MRI
Tord Hompland et al.
CANCER RESEARCH (2012)
Sphingosine-1-Phosphate Produced by Sphingosine Kinase 1 Promotes Breast Cancer Progression by Stimulating Angiogenesis and Lymphangiogenesis
Masayuki Nagahashi et al.
CANCER RESEARCH (2012)
Inhibition of lymphatic metastasis in neuroblastoma by a novel neutralizing antibody to vascular endothelial growth factor-D
Kenji Kashima et al.
CANCER SCIENCE (2012)
Papillary thyroid carcinoma involving cervical neck lymph nodes: correlations with lymphangiogenesis and ultrasound features
Yoonjung Choi et al.
ENDOCRINE JOURNAL (2012)
Type and location of tumor-infiltrating macrophages and lymphatic vessels predict survival of colorectal cancer patients
Annika Algars et al.
INTERNATIONAL JOURNAL OF CANCER (2012)
Lack of CCR7 expression is rate limiting for lymphatic spread of pancreatic ductal adenocarcinoma
Jan Sperveslage et al.
INTERNATIONAL JOURNAL OF CANCER (2012)
Relationship Between High Density of Peritumoral Lymphatic Vessels and Biological Behavior of Cervical Cancer
Song En-lin et al.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER (2012)
Induced lymphatic sinus hyperplasia in sentinel lymph nodes by VEGF-C as the earliest premetastatic indicator
Ruediger Liersch et al.
INTERNATIONAL JOURNAL OF ONCOLOGY (2012)
Cyclooxygenase-2 promotes tumor lymphangiogenesis and lymph node metastasis in oral squamous cell carcinoma
Yoshihiro Morita et al.
INTERNATIONAL JOURNAL OF ONCOLOGY (2012)
A sandwich-culture technique for controlling antibiotic production and morphological development in Streptomyces coelicolor
Inez P. de Jong et al.
JOURNAL OF MICROBIOLOGICAL METHODS (2012)
Lymphatic microvessel density and vascular endothelial growth factor-C and -D as prognostic factors in breast cancer: a systematic review and meta-analysis of the literature
Jun Wang et al.
MOLECULAR BIOLOGY REPORTS (2012)
SAR131675, a Potent and Selective VEGFR-3-TK Inhibitor with Antilymphangiogenic, Antitumoral, and Antimetastatic Activities
Antoine Alam et al.
MOLECULAR CANCER THERAPEUTICS (2012)
Lymphangiogenesis and biological behavior in pancreatic carcinoma and other pancreatic tumors
Zhongqiu Wang et al.
MOLECULAR MEDICINE REPORTS (2012)
Lack of Functioning Intratumoral Lymphatics in Colon and Pancreas Cancer Tissue
Waldemar L. Olszewski et al.
LYMPHATIC RESEARCH AND BIOLOGY (2012)
Characteristics of Multi-Organ Lymphangiectasia Resulting from Temporal Deletion of Calcitonin Receptor-Like Receptor in Adult Mice
Samantha L. Hoopes et al.
PLOS ONE (2012)
Collaborative interplay between FGF-2 and VEGF-C promotes lymphangiogenesis and metastasis
Renhai Cao et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Identification of CD146 expression, angiogenesis, and lymphangiogenesis as progression, metastasis, and poor-prognosis related markers for gallbladder adenocarcinoma
Wenjun Wang et al.
TUMOR BIOLOGY (2012)
The Transporter Spns2 Is Required for Secretion of Lymph but Not Plasma Sphingosine-1-Phosphate
Alejandra Mendoza et al.
CELL REPORTS (2012)
VEGF-C Promotes Immune Tolerance in B16 Melanomas and Cross-Presentation of Tumor Antigen by Lymph Node Lymphatics
Amanda W. Lund et al.
CELL REPORTS (2012)
Vascular Hyperpermeability, Angiogenesis, and Stroma Generation
Janice A. Nagy et al.
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2012)
Sentinel Lymph Node Pressure in Breast Cancer
S. David Nathanson et al.
ANNALS OF SURGICAL ONCOLOGY (2011)
Lymphatic vessel density as a predictor of lymph node metastasis and its relationship with prognosis in urothelial carcinoma of the bladder
Mi Zhou et al.
BJU INTERNATIONAL (2011)
Notch restricts lymphatic vessel sprouting induced by vascular endothelial growth factor
Wei Zheng et al.
BLOOD (2011)
Angiopoietin-1 and -2 Exert Antagonistic Functions in Tumor Angiogenesis, yet Both Induce Lymphangiogenesis
Ernesta Fagiani et al.
CANCER RESEARCH (2011)
Exosomes Released by Melanoma Cells Prepare Sentinel Lymph Nodes for Tumor Metastasis
Joshua L. Hood et al.
CANCER RESEARCH (2011)
Adrenomedullin and calcitonin gene-related peptide receptors in endocrine-related cancers: opportunities and challenges
Debbie L. Hay et al.
ENDOCRINE-RELATED CANCER (2011)
Angiopoietin-2 drives lymphatic metastasis of pancreatic cancer
Petra Schulz et al.
FASEB JOURNAL (2011)
Proteolytic processing of vascular endothelial growth factor-D is essential for its capacity to promote the growth and spread of cancer
Nicole C. Harris et al.
FASEB JOURNAL (2011)
A Single Institution Experience with Living Donor Liver Transplantation for Acute-on-Chronic Hepatitis B Liver Failure
Zheyu Chen et al.
HEPATO-GASTROENTEROLOGY (2011)
CD169-Positive Macrophages Dominate Antitumor Immunity by Crosspresenting Dead Cell-Associated Antigens
Kenichi Asano et al.
IMMUNITY (2011)
T Lymphocytes Negatively Regulate Lymph Node Lymphatic Vessel Formation
Raghu P. Kataru et al.
IMMUNITY (2011)
Lymphatic vascular morphogenesis in development, physiology, and disease
Stefan Schulte-Merker et al.
JOURNAL OF CELL BIOLOGY (2011)
Lipoxygenase mediates invasion of intrametastatic lymphatic vessels and propagates lymph node metastasis of human mammary carcinoma xenografts in mouse
Dontscho Kerjaschki et al.
JOURNAL OF CLINICAL INVESTIGATION (2011)
DC mobilization from the skin requires docking to immobilized CCL21 on lymphatic endothelium and intralymphatic crawling
Orna Tal et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2011)
Interleukin-6 signalling regulates vascular endothelial growth factor-C synthesis and lymphangiogenesis in human oral squamous cell carcinoma
Satoru Shinriki et al.
JOURNAL OF PATHOLOGY (2011)
Afferent lymph-derived T cells and DCs use different chemokine receptor CCR7-dependent routes for entry into the lymph node and intranodal migration
Asolina Braun et al.
NATURE IMMUNOLOGY (2011)
Regulated release of nitric oxide by nonhematopoietic stroma controls expansion of the activated T cell pool in lymph nodes
Veronika Lukacs-Kornek et al.
NATURE IMMUNOLOGY (2011)
The lymphatic vasculature in disease
Kari Alitalo
NATURE MEDICINE (2011)
Phosphorylation of Akt and ERK1/2 Is Required for VEGF-A/VEGFR2-Induced Proliferation and Migration of Lymphatic Endothelium
Michael T. Dellinger et al.
PLOS ONE (2011)
Photodynamic Ablation of Lymphatic Vessels and Intralymphatic Cancer Cells Prevents Metastasis
Tuomas Tammela et al.
SCIENCE TRANSLATIONAL MEDICINE (2011)
Development of Second-Generation VEGFR Tyrosine Kinase Inhibitors: Current Status
Pankaj Bhargava et al.
CURRENT ONCOLOGY REPORTS (2011)
COX-2-Mediated Regulation of VEGF-C in Association with Lymphangiogenesis and Lymph Node Metastasis in Lung Cancer
Huidong Liu et al.
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY (2010)
Intratumoral Lymphatics and Lymphatic Vessel Invasion Detected by D2-40 Are Essential for Lymph Node Metastasis in Bladder Transitional Cell Carcinoma
Yong Ma et al.
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY (2010)
High density of peritumoral lymphatic vessels is a potential prognostic marker of endometrial carcinoma: a clinical immunohistochemical method study
Ying Gao et al.
BMC CANCER (2010)
CXCR4 Signaling Regulates Metastasis of Chemoresistant Melanoma Cells by a Lymphatic Metastatic Niche
Minah Kim et al.
CANCER RESEARCH (2010)
Suppression of Tumor Growth and Metastasis by Simultaneously Blocking Vascular Endothelial Growth Factor (VEGF)-A and VEGF-C with a Receptor-Immunoglobulin Fusion Protein
Dapeng Zhang et al.
CANCER RESEARCH (2010)
Quantitative Imaging of Lymphatic Function with Liposomal Indocyanine Green
Steven T. Proulx et al.
CANCER RESEARCH (2010)
Integrin α4β1 Signaling Is Required for Lymphangiogenesis and Tumor Metastasis
Barbara Garmy-Susini et al.
CANCER RESEARCH (2010)
VEGFR-3 ligand-binding and kinase activity are required for lymphangiogenesis but not for angiogenesis
Luqing Zhang et al.
CELL RESEARCH (2010)
Transmural Flow Modulates Cell and Fluid Transport Functions of Lymphatic Endothelium
Dimana O. Miteva et al.
CIRCULATION RESEARCH (2010)
Vascular Endothelial Growth Factor Receptors VEGFR-2 and VEGFR-3 Are Localized Primarily to the Vasculature in Human Primary Solid Cancers
Neil R. Smith et al.
CLINICAL CANCER RESEARCH (2010)
Neuropilin-2 mediates VEGF-C-induced lymphatic sprouting together with VEGFR3
Yunling Xu et al.
JOURNAL OF CELL BIOLOGY (2010)
Activated regulatory T cells are the major T cell type emigrating from the skin during a cutaneous immune response in mice
Michio Tomura et al.
JOURNAL OF CLINICAL INVESTIGATION (2010)
Lymphatic endothelial cell sphingosine kinase activity is required for lymphocyte egress and lymphatic patterning
Trung H. M. Pham et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2010)
Lymph node-resident lymphatic endothelial cells mediate peripheral tolerance via Aire-independent direct antigen presentation
Jarish N. Cohen et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2010)
Lymph node fibroblastic reticular cells directly present peripheral tissue antigen under steady-state and inflammatory conditions
Anne L. Fletcher et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2010)
Significance of Lymphangiogenesis in Primary Tumor and Draining Lymph Nodes During Lymphatic Metastasis of Pancreatic Head Cancer
Hiroshi Kurahara et al.
JOURNAL OF SURGICAL ONCOLOGY (2010)
Peritumoral Lymphatic Microvessel Density Associated with Tumor Progression and Poor Prognosis in Gastric Carcinoma
Ugur Coskun et al.
JOURNAL OF SURGICAL RESEARCH (2010)
EphB4 Promotes Site-Specific Metastatic Tumor Cell Dissemination by Interacting with Endothelial Cell-Expressed EphrinB2
Melanie Heroult et al.
MOLECULAR CANCER RESEARCH (2010)
Ephrin-B2 regulates VEGFR2 function in developmental and tumour angiogenesis
Suphansa Sawamiphak et al.
NATURE (2010)
Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis
Yingdi Wang et al.
NATURE (2010)
FDA Drug Approval Summary: Bevacizumab plus Interferon for Advanced Renal Cell Carcinoma
Jeff Summers et al.
ONCOLOGIST (2010)
Phage-Derived Fully Human Monoclonal Antibody Fragments to Human Vascular Endothelial Growth Factor-C Block Its Interaction with VEGF Receptor-2 and 3
Matthias Rinderknecht et al.
PLOS ONE (2010)
Lymph node cortical sinus organization and relationship to lymphocyte egress dynamics and antigen exposure
Irina L. Grigorova et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Nodal Lymphangiogenesis and Metastasis Role of Tumor-Induced Lymphatic Vessel Activation in Extramammary Paget's Disease
Satoshi Hirakawa et al.
AMERICAN JOURNAL OF PATHOLOGY (2009)
Vascular Endothelial Growth Factor D and Intratumoral Lymphatics as Independent Prognostic Factors in Epithelial Ovarian Carcinoma
Lichun Li et al.
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY (2009)
Tumor-Associated Lymphangiogenesis Correlates with Prognosis after Resection of Human Hepatocellular Carcinoma
Armin Thelen et al.
ANNALS OF SURGICAL ONCOLOGY (2009)
Clinical implications of increased lymph vessel density in the lymphatic metastasis of early-stage invasive cervical carcinoma: a clinical immunohistochemical method study
Shi-qian Zhang et al.
BMC CANCER (2009)
Vascular Endothelial Growth Factor-C and C-C Chemokine Receptor 7 in Tumor Cell-Lymphatic Cross-talk Promote Invasive Phenotype
Arnine Issa et al.
CANCER RESEARCH (2009)
From tumor lymphangiogenesis to lymphvascular niche
Satoshi Hirakawa
CANCER SCIENCE (2009)
Drug delivery to the lymphatic system: importance in future cancer diagnosis and therapies
Yumei Xie et al.
EXPERT OPINION ON DRUG DELIVERY (2009)
Inflamed Lymphatic Endothelium Suppresses Dendritic Cell Maturation and Function via Mac-1/ICAM-1-Dependent Mechanism
Simona Podgrabinska et al.
JOURNAL OF IMMUNOLOGY (2009)
Visualization of Tumor Blockage and Rerouting of Lymphatic Drainage in the Penile Cancer Patients by Use of SPECT/CT
Joost A. P. Leijte et al.
JOURNAL OF NUCLEAR MEDICINE (2009)
VEGF-D deficiency in mice does not affect embryonic or postnatal lymphangiogenesis but reduces lymphatic metastasis
Marta Koch et al.
JOURNAL OF PATHOLOGY (2009)
Lymphatic vessels: Pressure- and flow-dependent regulatory reactions
Anatoliy A. Gashev
LYMPHATIC CONTINUUM REVISITED (2008)
Structure and function of rat lymph nodes
Osamu Ohtani et al.
ARCHIVES OF HISTOLOGY AND CYTOLOGY (2008)
Role of VEGF-D and VEGFR-3 in developmental lymphangiogenesis, a chemicogenetic study in Xenopus tadpoles
Annelii Ny et al.
BLOOD (2008)
Sphingosine-1-phosphate promotes lymphangiogenesis by stimulating S1P1/Gi/PLC/Ca2+ signaling pathways
Chang Min Yoon et al.
BLOOD (2008)
Blocking neuropilin-2 function inhibits tumor cell metastasis
Maresa Caunt et al.
CANCER CELL (2008)
Combination therapy with short interfering RNA vectors against VEGF-C and VEGF-A suppresses lymph node and lung metastasis in a mouse immunocompetent mammary cancer model
M-A Shibata et al.
CANCER GENE THERAPY (2008)
Clinicopathological significance of peritumoral lymphatic vessel density in gastric carcinoma
Peng Gao et al.
CANCER LETTERS (2008)
A novel gene expression profile in lymphatics associated with tumor growth and nodal metastasis
Steven Clasper et al.
CANCER RESEARCH (2008)
Predicting lymph node status in early gastric cancer
Robert Michael Kwee et al.
GASTRIC CANCER (2008)
Cyclooxygenase-2 up-regulates CCR7 via EP2/EP4 receptor signaling pathways to enhance lymphatic invasion of breast cancer cells
Mei-Ren Pan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Adrenomedullin signaling is necessary for murine lymphatic vascular development
Kimberly L. Fritz-Six et al.
JOURNAL OF CLINICAL INVESTIGATION (2008)
Intratumoral lymphangiogenesis in oral squamous cell carcinoma and its clinicopathological significance
D. Zhao et al.
JOURNAL OF ORAL PATHOLOGY & MEDICINE (2008)
Intralymphatic chemotherapy using a hyaluronan-cisplatin conjugate
Shuang Cai et al.
JOURNAL OF SURGICAL RESEARCH (2008)
Roles of Integrins in Tumor Angiogenesis and Lymphangiogenesis
Barbara Garmy-Susini et al.
Lymphatic Research and Biology (2008)
Structural diversity of G protein-coupled receptors and significance for drug discovery
Malin C. Lagerstrom et al.
NATURE REVIEWS DRUG DISCOVERY (2008)
Intratumoral lymphangiogenesis of esophageal squamous cell carcinoma and relationship with regulatory factors and prognosis
Akemi Inoue et al.
PATHOLOGY INTERNATIONAL (2008)
Intratumoral lymphatics and lymphatic invasion are associated with tumor aggressiveness and poor prognosis in renal cell carcinoma
Akio Horiguchi et al.
UROLOGY (2008)
Integrins in angiogenesis and lymphangiogenesis
Christie J. Avraamides et al.
NATURE REVIEWS CANCER (2008)
Therapeutic differentiation and maturation of lymphatic vessels after lymph node dissection and transplantation
Tuomas Tammela et al.
NATURE MEDICINE (2007)
VEGF-A produced by chronically inflamed tissue induces lymphangiogenesis in draining lymph nodes
Cornelia Halin et al.
BLOOD (2007)
Lineage tracing demonstrates the venous origin of the mammalian lymphatic vasculature
R. Sathish Srinivasan et al.
GENES & DEVELOPMENT (2007)
Functionally specialized junctions between endothelial cells of lymphatic vessels
Peter Baluk et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2007)
Making a tumour's bed: glioblastoma stem cells and the vascular niche
Richard J. Gilbertson et al.
NATURE REVIEWS CANCER (2007)
Increased sentinel lymph node lymphangiogenesis is associated with nonsentinel axillary lymph node involvement in breast cancer patients with a positive sentinel node
Gert G. Van den Eynden et al.
CLINICAL CANCER RESEARCH (2007)
Radiogenic lymphangiogenesis in the skin
Susanne Jackowski et al.
AMERICAN JOURNAL OF PATHOLOGY (2007)
Distinct vascular endothelial growth factor signals for lymphatic vessel enlargement and sprouting
Maria Wirzenius et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2007)
Prognostic significance of vascular endothelial cell growth factors -A, -C and -D in breast cancer and their relationship with angio- and lymphangiogenesis
R. A. A. Mohammed et al.
BRITISH JOURNAL OF CANCER (2007)
Lymphatic vessel density in pulmonary adenocarcinoma immunohistochemically evaluated with anti-podoplanin or anti-D2-40 antibody is correlated with lymphatic invasion or lymph node metastases
Yoshin Adachi et al.
PATHOLOGY INTERNATIONAL (2007)
Lymphatic microvessel density is an independent prognostic factor in colorectal cancer
Kentaro Matsumoto et al.
DISEASES OF THE COLON & RECTUM (2007)
VEGF-C-induced lymphangiogenesis in sentinel lymph nodes promotes tumor metastasis to distant sites
Satoshi Hirakawa et al.
BLOOD (2007)
Tumor-induced sentinel lymph node lymphangiogenesis and increased lymph flow precede melanoma metastasis
Maria I. Harrell et al.
AMERICAN JOURNAL OF PATHOLOGY (2007)
Anatomy of the lymphatics
John E. Skandalakis et al.
SURGICAL ONCOLOGY CLINICS OF NORTH AMERICA (2007)
Induction of lymphangiogenesis in and around axillary lymph node metastases of patients with breast cancer
G. G. Van den Eynden et al.
BRITISH JOURNAL OF CANCER (2006)
Preparing the soil: The primary tumor induces vasculature reorganization in the sentinel lymph node before the arrival of metastatic cancer cells
Chao-Nan Qian et al.
CANCER RESEARCH (2006)
Imaging steps of lymphatic metastasis reveals that vascular endothelial growth factor-C increases metastasis by increasing delivery of cancer cells to lymph nodes: Therapeutic implications.
Tohru Hoshida et al.
CANCER RESEARCH (2006)
ESAM supports neutrophil extravasation, activation of Rho, and VEGF-induced vascular permeability
Frank Wegmann et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2006)
Functional interaction of VEGF-C and VEGF-D with neuropilin receptors
Terhi Karpanen et al.
FASEB JOURNAL (2006)
VEGF-C expressing tumor-associated macrophages in lymphnode positive breast cancer: impact on lymphangiogenesis and survival
Sebastian F. Schoppmann et al.
SURGERY (2006)
Hepatocyte growth factor is a lymphanoiogenic factor with an indirect mechanism of action
RH Cao et al.
BLOOD (2006)
Signal transduction by VEGF receptors in regulation of angiogenesis and lymphangiogenesis
M Shibuya et al.
EXPERIMENTAL CELL RESEARCH (2006)
Inhibtion of VEGFR-3 activation with the antagonistic antibody more potently suppresses lymph node and distant metastases than inactivation of VEGFR-2
N Roberts et al.
CANCER RESEARCH (2006)
B cell-driven lymphangiogenesis in inflamed lymph nodes enhances dendritic cell mobilization
V Angeli et al.
IMMUNITY (2006)
Lymphatic vessel density, nodal metastases, and prognosis in patients with head and neck cancer
N Audet et al.
ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY (2005)
Direct recruitment of CRK and GRB2 to VEGFR-3 induces proliferation, migration, and survival of endothelial cells through the activation of ERK, AKT, and JNK pathways
A Salameh et al.
BLOOD (2005)
Insulin-like growth factors 1 and 2 induce lymphangiogenesis in vivo
M Björndahl et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Lymphangiogenesis correlates with lymph node metastasis, prognosis, and angiogenic phenotype in human non-small cell lung cancer
F Renyi-Vamos et al.
CLINICAL CANCER RESEARCH (2005)
Prediction of lymph node metastasis in colorectal carcinoma by expression of chemokine receptor CCR7
K Günther et al.
INTERNATIONAL JOURNAL OF CANCER (2005)
Tumor lymphangiogenesis predicts melanoma metastasis to sentinel lymph nodes
SS Dadras et al.
MODERN PATHOLOGY (2005)
Hepatocyte growth factor promotes lymphatic vessel formation and function
K Kajiya et al.
EMBO JOURNAL (2005)
Inhibition of lymphogenous metastasis using adeno-associated virus-mediated gene transfer of a soluble VEGFR-3 decoy receptor
JM Lin et al.
CANCER RESEARCH (2005)
Evidence for lymphangiogenesis and its prognostic implications in head and neck squamous cell carcinoma
PA Kyzas et al.
JOURNAL OF PATHOLOGY (2005)
Vascular endothelial cell growth factor receptor 3-mediated activation of lymphatic endothelium is crucial for tumor cell entry and spread via lymphatic vessels
YL He et al.
CANCER RESEARCH (2005)
Lymph vessel density correlates with nodal status, VEGF-C expression, and prognosis in breast cancer
Y Nakamura et al.
BREAST CANCER RESEARCH AND TREATMENT (2005)
VEGF-A induces tumor and sentinel lymph node lymphangiogenesis and promotes lymphatic metastasis
S Hirakawa et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2005)
Vascular endothelial growth factor d is dispensable for development of the lymphatic system
ME Baldwin et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
PDZ interaction site in ephrinB2 is required for the remodeling of lymphatic vasculature
T Mäkinen et al.
GENES & DEVELOPMENT (2005)
VEGF-A promotes tissue repair-associated lymphatic vessel formation via VEGFR-2 and the α1β1 and α2β1 integrins
YK Hong et al.
FASEB JOURNAL (2004)
PDGF-BB induces intratumoral lymphangiogenesis and promotes lymphatic metastasis
RH Cao et al.
CANCER CELL (2004)
Induction of cutaneous delayed-type hypersensitivity reactions in VEGF-A transgenic mice results in chronic skin inflammation associated with persistent lymphatic hyperplasia
R Kunstfeld et al.
BLOOD (2004)
Dose-dependent response of FGF-2 for lymphangiogenesis
LK Chang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins
MJ Karkkainen et al.
NATURE IMMUNOLOGY (2004)
High LYVE-1-positive lymphatic vessel numbers are associated with poor outcome in breast cancer
P Bono et al.
CLINICAL CANCER RESEARCH (2004)
Vascular endothelial growth factor C and vascular endothelial growth factor receptor 3 expression in squamous cell carcinomas of the head and neck
C Neuchrist et al.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK (2003)
Tumor lymphangiogenesis - A novel prognostic indicator for cutaneous melanoma metastasis and survival
SS Dadras et al.
AMERICAN JOURNAL OF PATHOLOGY (2003)
Identification of vascular lineage-specific genes by transcriptional profiling of isolated blood vascular and lymphatic endothelial cells
S Hirakawa et al.
AMERICAN JOURNAL OF PATHOLOGY (2003)
Vascular permeability factor/vascular endothelial growth factor induces lymphangiogenesis as well as angiogenesis
JA Nagy et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2002)
Lymphangiogenic gene therapy with minimal blood vascular side effects
A Saaristo et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2002)
Tumor-associated macrophages express lymphatic endothelial growth factors and are related to peritumoral lymphangiogenesis
SF Schoppmann et al.
AMERICAN JOURNAL OF PATHOLOGY (2002)
Blockade of vascular endothelial growth factor receptor-3 signaling inhibits fibroblast growth factor-2-induced lymphangiogenesis in mouse cornea
H Kubo et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Lymphatic metastasis in the absence of functional intratumor lymphatics
TP Padera et al.
SCIENCE (2002)
EphB ligand, ephrinB2, suppresses the VEGF- and angiopoietin-1-induced Ras/mitogen-activated protein kinase pathway in venous endothelial cells
I Kim et al.
FASEB JOURNAL (2002)
A model for gene therapy of human hereditary lymphedema
MJ Karkkainen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF-C/D receptor VEGFR-3
T Mäkinen et al.
EMBO JOURNAL (2001)
The specificity of receptor binding by vascular endothelial growth factor-D is different in mouse and man
ME Baldwin et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Involvement of chemokine receptors in breast cancer metastasis
A Müller et al.
NATURE (2001)
Vascular endothelial growth factor-C-mediated lymphangiogenesis promotes tumour metastasis
SJ Mandriota et al.
EMBO JOURNAL (2001)
Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis
M Skobe et al.
NATURE MEDICINE (2001)
VEGF-D promotes the metastatic spread of tumor cells via the lymphatics
SA Stacker et al.
NATURE MEDICINE (2001)
Inhibition of lymphangiogenesis with resulting lymphedema in transgenic mice expressing soluble VEGF receptor-3
T Mäkinen et al.
NATURE MEDICINE (2001)
Monoclonal antibodies to vascular endothelial growth factor-D block its interactions with both VEGF receptor-2 and VEGF receptor-3
MG Achen et al.
EUROPEAN JOURNAL OF BIOCHEMISTRY (2000)
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