4.1 Article

Synthesis, and docking studies of novel tetrazole-S-alkyl derivatives as antimicrobial agents

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Chemistry, Multidisciplinary

Microwave-Assisted Synthesis, Antimicrobial Activities and Molecular Docking of Methoxycarboxylated Chalcone Derived Pyrazoline and Pyrazole Derivatives

Saba Farooq et al.

Summary: This study designed a series of heterocyclic chalcone derivatives and evaluated their antimicrobial activity against Staphylococcus aureus and Escherichia coli. The results showed that carboxylated pyrazoline derivatives exhibited strong inhibition activity against Staphylococcus aureus. Additionally, molecular docking analysis demonstrated that pyrazoline derivatives had better antimicrobial activity compared to chalcone and pyrazole derivatives.

CHEMISTRYSELECT (2022)

Article Chemistry, Physical

Synthesis, molecular modeling, quantum mechanical calculations and ADME estimation studies of benzimidazole-oxadiazole derivatives as potent antifungal agents

Ulviye Acar cevik et al.

Summary: A series of new compounds were designed and synthesized as potential antifungal agents, with compounds 4a and 4b showing better inhibitory activity against Candida albicans than ketoconazole. Molecular docking studies and 100 ns simulations revealed stable interactions between the lead compounds and target proteins, supporting their further analysis as antifungal candidates.

JOURNAL OF MOLECULAR STRUCTURE (2022)

Article Chemistry, Multidisciplinary

Design, Synthesis, and Molecular Modeling Studies of a Novel Benzimidazole as an Aromatase Inhibitor

Ulviye Acar Cevik et al.

Summary: In this study, a series of novel 1,3,4-oxadiazole-benzimidazole derivatives were designed and synthesized. Their cytotoxic activities against five cancer cell lines were evaluated, and compounds 5b,c showed satisfactory potencies and higher anticancer activity compared to the reference drug doxorubicin. Enzymatic inhibition assays of aromatase enzymes were performed, and molecular docking and dynamics simulations were used to understand the structure-activity connections and mechanism of action of the aromatase inhibitors.

ACS OMEGA (2022)

Article Chemistry, Physical

New s-Triazine/Tetrazole conjugates as potent antifungal and antibacterial agents: Design, molecular docking and mechanistic study

Ramadan Ahmed Mekheimer et al.

Summary: A novel class of heterocyclic compounds was synthesized using a convenient synthetic method, and their antimicrobial and antifungal activities were screened. The results showed that these compounds exhibited strong antibacterial and antifungal properties against certain bacteria and fungi, and demonstrated good drug-likeness.

JOURNAL OF MOLECULAR STRUCTURE (2022)

Review Materials Science, Multidisciplinary

Polymeric approach to combat drug-resistant methicillin-resistant Staphylococcus aureus

Shreya Kanth et al.

Summary: The current global death rate is threatened by deadly unknown infections and the emergence of multidrug-resistant bacteria. Combatting drug-resistant bacteria, such as MRSA, has become a daunting challenge globally, with polymer synthesis being explored as a significant approach in preventing the spread of infections.

JOURNAL OF MATERIALS SCIENCE (2021)

Article Biochemistry & Molecular Biology

Synthesis, anticancer evaluation and molecular docking studies of new benzimidazole-1,3,4-oxadiazole derivatives as human topoisomerase types I poison

Ulviye Acar Cevik et al.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2020)

Review Environmental Sciences

Applications and challenges of elemental sulfur, nanosulfur, polymeric sulfur, sulfur composites, and plasmonic nanostructures

Yong Teng et al.

CRITICAL REVIEWS IN ENVIRONMENTAL SCIENCE AND TECHNOLOGY (2019)

Proceedings Paper Materials Science, Multidisciplinary

Design and antimicrobial activity of piperazine polymer nanocomposite

Manohara Dhulappa Jalageri et al.

MATERIALS TODAY-PROCEEDINGS (2019)

Proceedings Paper Materials Science, Multidisciplinary

Synthesis of environmental-friendly polymer nanocomposite against pathogenic microorganism

N. Akshatha et al.

MATERIALS TODAY-PROCEEDINGS (2019)

Article Materials Science, Biomaterials

Preparation of sulfur nanoparticles and their antibacterial activity and cytotoxic effect

Shiv Shankar et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2018)

Review Respiratory System

Defining antimicrobial resistance in cystic fibrosis

Timothy J. Kidd et al.

JOURNAL OF CYSTIC FIBROSIS (2018)

Review Biochemistry & Molecular Biology

Tetrazolium Compounds: Synthesis and Applications in Medicine

Cheng-Xi Wei et al.

MOLECULES (2015)

Article Biochemistry & Molecular Biology

Novel 3-arylfuran-2(5H)-one-fluoroquinolone hybrid: Design, synthesis and evaluation as antibacterial agent

Xu-Dong Wang et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2014)

Article Chemistry, Organic

Synthesis of Saturated N-Heterocycles

Cam-Van T. Vo et al.

JOURNAL OF ORGANIC CHEMISTRY (2014)

Article Chemistry, Medicinal

Correlation of hydrogen-bonding propensity and anticancer profile of tetrazole-tethered combretastatin analogues

Ganesh S. Jedhe et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2013)

Article Biochemistry & Molecular Biology

Synthesis of eperezolid-like molecules and evaluation of their antimicrobial activities

Meltem Yolal et al.

RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY (2012)

Article Biochemistry & Molecular Biology

Chloroalkyl piperazine and nitrogen mustard porphyrins: synthesis and anticancer activity

CC Guo et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2004)

Article Infectious Diseases

History of the development of azole derivatives

JA Maertens

CLINICAL MICROBIOLOGY AND INFECTION (2004)