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Molecular Requirements for Ethanol Differential Allosteric Modulation of Glycine Receptors Based on Selective Gβγ Modulation
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JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Serotonin receptor 1A-modulated phosphorylation of glycine receptor α3 controls breathing in mice
Till Manzke et al.
JOURNAL OF CLINICAL INVESTIGATION (2010)
Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis
Volker Brinkmann et al.
NATURE REVIEWS DRUG DISCOVERY (2010)
An intramembrane aromatic network determines pentameric assembly of Cys-loop receptors
Svenja Haeger et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2010)
Lack of positive allosteric modulation of mutated α1S267I glycine receptors by cannabinoids
Nilufar Foadi et al.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2010)
Recommendations for the Pharmacological Management of Neuropathic Pain: An Overview and Literature Update
Robert H. Dworkin et al.
MAYO CLINIC PROCEEDINGS (2010)
Injured nerve-derived COX2/PGE2 contributes to the maintenance of neuropathic pain in aged rats
Weiya Ma et al.
NEUROBIOLOGY OF AGING (2010)
Zinc enhances ethanol modulation of the α1 glycine receptor
Lindsay M. McCracken et al.
NEUROPHARMACOLOGY (2010)
Synthesis of heteroaromatic tropeines and heterogeneous binding to glycine receptors
Gabor Maksay et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2009)
Novel Regulatory Site within the TM3-4 Loop of Human Recombinant α3 Glycine Receptors Determines Channel Gating and Domain Structure
Hans-Georg Breitinger et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
A Lipid-dependent Uncoupled Conformation of the Acetylcholine Receptor
Corrie J. B. daCosta et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Anionic Lipids Allosterically Modulate Multiple Nicotinic Acetylcholine Receptor Conformational Equilibria
Corrie J. B. daCosta et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Different binding modes of tropeines mediating inhibition and potentiation of α1 glycine receptors
Gabor Maksay et al.
JOURNAL OF NEUROCHEMISTRY (2009)
Substance P Drives Endocannabinoid-Mediated Disinhibition in a Midbrain Descending Analgesic Pathway
Geoffrey M. Drew et al.
JOURNAL OF NEUROSCIENCE (2009)
X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation
Nicolas Bocquet et al.
NATURE (2009)
Native glycine receptor subtypes and their physiological roles
Joseph W. Lynch
NEUROPHARMACOLOGY (2009)
The Nonpsychotropic Cannabinoid Cannabidiol Modulates and Directly Activates Alpha-1 and Alpha-1-Beta Glycine Receptor Function
Joerg Ahrens et al.
PHARMACOLOGY (2009)
Glycine transporter inhibitors as a novel drug discovery strategy for neuropathic pain
Toshihiro Dohi et al.
PHARMACOLOGY & THERAPEUTICS (2009)
Localization of glycine receptors in the human forebrain, brainstem, and cervical spinal cord: an immunohistochemical review
Kristin Baer et al.
FRONTIERS IN MOLECULAR NEUROSCIENCE (2009)
A Transmembrane Residue Influences the Interaction of Propofol with the Strychnine-Sensitive Glycine α1 and α1β Receptor
Joerg Ahrens et al.
ANESTHESIA AND ANALGESIA (2008)
Glycine transporter inhibitors as a potential therapeutic strategy for chronic pain with memory impairment
Mitsuo Tanabe et al.
ANESTHESIOLOGY (2008)
Subunit-specific modulation of glycine receptors by cannabinoids and N-arachidonyl-glycine
Zhe Yang et al.
BIOCHEMICAL PHARMACOLOGY (2008)
Sesterterpenoids from the sponge Sarcotragus sp.
Nan Wang et al.
JOURNAL OF NATURAL PRODUCTS (2008)
Targets for ethanol action and antagonism in Loop 2 of the extracellular domain of glycine receptors
Daya I. Perkins et al.
JOURNAL OF NEUROCHEMISTRY (2008)
Actions of N-arachidonyl-glycine in a rat neuropathic pain model
Leeza A. Q. Wong et al.
NEUROPHARMACOLOGY (2008)
Does COX2-dependent PGE2 play a role in neuropathic pain?
Weiya Ma et al.
NEUROSCIENCE LETTERS (2008)
Spinal dis-inhibition in inflammatory pain
Hanns Ulrich Zeilhofer et al.
NEUROSCIENCE LETTERS (2008)
Pharmacological blockade of the vanilloid receptor TRPV1 elicits marked hyperthermia in humans
Narender R. Gavva et al.
PAIN (2008)
A selective Gβγ-linked intracellular mechanism for modulation of a ligand-gated ion channel by ethanol
Gonzalo E. Yevenes et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Depletion of vesicular zinc in dorsal horn of spinal cord causes increased neuropathic pain in mice
Seung Mook Jo et al.
BIOMETALS (2008)
Cross-linking of sites involved with alcohol action between transmembrane segments 1 and 3 of the glycine receptor following activation
Ingrid A. Lobo et al.
JOURNAL OF NEUROCHEMISTRY (2008)
Sativex successfully treats neuropathic pain characterised by allodynia: A randomised, double-blind, placebo-controlled clinical trial
Turo J. Nurmikko et al.
PAIN (2007)
Zinc enhances the inhibitory effects of strychnine-sensitive glycine receptors in mouse hippocampal neurons
Hai Xia Zhang et al.
JOURNAL OF NEUROPHYSIOLOGY (2007)
Glycine Inhibitory Dysfunction Turns Touch into Pain through PKCgamma Interneurons
Lois S. Miraucourt et al.
PLOS ONE (2007)
Mechanisms of homomeric α1 glycine receptor endocytosis
Renqi Huang et al.
BIOCHEMISTRY (2007)
Evidence that ethanol acts on a target in Loop 2 of the extracellular domain of α1 glycine receptors
Daniel K. Crawford et al.
JOURNAL OF NEUROCHEMISTRY (2007)
Actions of N-arachidonyl-glycine in a rat inflammatory pain model
Rebecca Succar et al.
MOLECULAR PAIN (2007)
Effects of a mutation in the TM2-TM3 linker region of the glycine receptor α1 subunit on gating and allosteric modulation
Michelle L. Dupre et al.
BRAIN RESEARCH (2007)
Tropisetron modulation of the glycine receptor: femtomolar potentiation and a molecular determinant of inhibition
Zhe Yang et al.
JOURNAL OF NEUROCHEMISTRY (2007)
Changes in spinal and supraspinal endocannabinoid levels in neuropathic rats
Stefania Petrosino et al.
NEUROPHARMACOLOGY (2007)
Lipids and lipid-based formulations: optimizing the oral delivery of lipophilic drugs
Christopher J. H. Porter et al.
NATURE REVIEWS DRUG DISCOVERY (2007)
Molecular determinants for G protein βγ modulation of ionotropic glycine receptors
Gonzalo E. Yevenes et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Modulation of temperature-sensitive TRP channels
Jiehong Huang et al.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2006)
Hyperekplexia phenotype of glycine receptor α1 subunit mutant mice identifies Zn2+ as an essential endogenous modulator of glycinergic neurotransmission
Klaus Hirzel et al.
NEURON (2006)
TRPV1: a therapeutic target for novel analgesic drugs?
Arpad Szallasi et al.
TRENDS IN MOLECULAR MEDICINE (2006)
Concentrations of extracellular free zinc (pZn)e in the central nervous system during simple anesthetization, ischemia and reperfusion
CJ Frederickson et al.
EXPERIMENTAL NEUROLOGY (2006)
Δ9-Tetrahydrocannabinol and endogenous cannabinoid anandamide directly potentiate the function of glycine receptors
N Hejazi et al.
MOLECULAR PHARMACOLOGY (2006)
5-HT3 receptors
A. J. Thompson et al.
CURRENT PHARMACEUTICAL DESIGN (2006)
Molecular basis for zinc potentiation at strychnine-sensitive glycine receptors
PS Miller et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Fluorescence and molecular dynamics studies of the acetylcholine receptor γM4 transmembrane peptide in reconstituted systems
SS Antollini et al.
MOLECULAR MEMBRANE BIOLOGY (2005)
Glycine receptors in CNS neurons as a target for nonretrograde action of cannabinoids
N Lozovaya et al.
JOURNAL OF NEUROSCIENCE (2005)
Ethanol withdrawal-associated allodynia and hyperalgesia:: Age-dependent regulation by protein kinase Cε and γ isozymes
JA Shumilla et al.
JOURNAL OF PAIN (2005)
An endocannabinoid mechanism for stress-induced analgesia
AG Hohmann et al.
NATURE (2005)
The β subunit determines the ligand binding properties of synaptic glycine receptors
J Grudzinska et al.
NEURON (2005)
The glycinergic control of spinal pain processing
HU Zeilhofer
CELLULAR AND MOLECULAR LIFE SCIENCES (2005)
Synthesis of tropeines and allosteric modulation of ionotropic glycine receptors
G Maksay et al.
JOURNAL OF MEDICINAL CHEMISTRY (2004)
Simvastatin: a review
TR Pedersen et al.
EXPERT OPINION ON PHARMACOTHERAPY (2004)
Changes on the properties of glycine receptors during neuronal development
LG Aguayo et al.
BRAIN RESEARCH REVIEWS (2004)
Laminar distribution of GABAA- and glycine-receptor mediated tonic inhibition in the dorsal horn of the rat lumbar spinal cord:: effects of picrotoxin and strychnine on expression of Fos-like immunoreactivity
JN Cronin et al.
PAIN (2004)
Multiple sites of ethanol action in α1 and α2 glycine receptors suggested by sensitivity to pressure antagonism
DL Davies et al.
JOURNAL OF NEUROCHEMISTRY (2004)
Treatment of chronic low back pain with tropisetron
T Stratz et al.
SCANDINAVIAN JOURNAL OF RHEUMATOLOGY (2004)
GlyR α3:: An essential target for spinal PGE2-mediated inflammatory pain sensitization
RJ Harvey et al.
SCIENCE (2004)
The interaction of anaesthetic steroids with recombinant glycine and GABAA receptors
CJ Weir et al.
BRITISH JOURNAL OF ANAESTHESIA (2004)
Four PGE2 EP receptors are up-regulated in injured nerve following partial sciatic nerve ligation
WY Ma et al.
EXPERIMENTAL NEUROLOGY (2003)
Modulation of glycine-activated ion channel function by G-protein βγ subunits
GE Yevenes et al.
NATURE NEUROSCIENCE (2003)
Activation of presynaptic glycine receptors facilitates glycine release from presynaptic terminals synapsing onto rat spinal sacral dorsal commissural nucleus neurons
HJ Jeong et al.
JOURNAL OF PHYSIOLOGY-LONDON (2003)
Role of 5-HT3 receptors in the mechanisms of central pain syndrome
ML Kukushkin et al.
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE (2003)
Molecular volume determines the activity of the halogenated alkane bromoform at wild-type and mutant GABAA receptors
TL Kash et al.
BRAIN RESEARCH (2003)
New cytotoxic sesterterpenoids and norsesterterpenoids from two sponges of the genus Sarcotragus
YH Liu et al.
JOURNAL OF NATURAL PRODUCTS (2003)
Association of gephyrin and glycine receptors in the human brainstem and spinal cord: An immuniphistochemical analysis
K Baer et al.
NEUROSCIENCE (2003)
Kinetic properties of the alpha(2) homo-oligomeric glycine receptor impairs a proper synaptic functioning
JA Mangin et al.
JOURNAL OF PHYSIOLOGY-LONDON (2003)
The relationship between blood glucose excursions and painful diabetic peripheral neuropathy: a pilot study
SO Oyibo et al.
DIABETIC MEDICINE (2002)
Binding site stoichiometry and the effects of phosphorylation on human α1 homomeric glycine receptors
LJ Gentet et al.
JOURNAL OF PHYSIOLOGY-LONDON (2002)
Cation-selective mutations in the M2 domain of the inhibitory glycine receptor channel reveal determinants of ion-charge selectivity
A Keramidas et al.
JOURNAL OF GENERAL PHYSIOLOGY (2002)
PGE(2) selectively blocks inhibitory glycinergic neurotransmission onto rat superficial dorsal horn neurons
S Ahmadi et al.
NATURE NEUROSCIENCE (2002)
Identification of a new class of molecules, the arachidonyl amino acids, and characterization of one member that inhibits pain
SM Huang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Ubiquitination precedes internalization and proteolytic cleavage of plasma membrane-bound glycine receptors
C Büttner et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Subunit-specific modulation of glycine receptors by neurosteroids
G Maksay et al.
NEUROPHARMACOLOGY (2001)
Zinc co-localizes with GABA and glycine in synapses in the lamprey spinal cord
A Birinyi et al.
JOURNAL OF COMPARATIVE NEUROLOGY (2001)
Ivermectin, an unconventional agonist of the glycine receptor chloride channel
Q Shan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Sarcotragins A and B, new sesterterpenoid alkaloids from the sponge Sarcotragus sp.
J Shin et al.
TETRAHEDRON LETTERS (2001)
Conformational flexibility of tricine as a chelating agent in catena-poly[[(tricinato)copper(II)]-mu-chloro]
MR Silva et al.
ACTA CRYSTALLOGRAPHICA SECTION C-STRUCTURAL CHEMISTRY (2001)
Effects of membrane cholesterol on the sensitivity of the GABA(A) receptor to GABA in acutely dissociated rat hippocampal neurones
T Sooksawate et al.
NEUROPHARMACOLOGY (2001)
Glycine receptor β subunits play a critical role in potentiation of glycine responses by ICS-205,930
S Supplisson et al.
MOLECULAR PHARMACOLOGY (2000)
Tropisetron - An update of its use in the prevention of chemotherapy-induced nausea and vomiting
K Simpson et al.
DRUGS (2000)
Oxidative metabolism of anandamide
SH Burstein et al.
PROSTAGLANDINS & OTHER LIPID MEDIATORS (2000)
The actions of ether, alcohol and alkane general anaesthetics on GABAA and glycine receptors and the effects of TM2 and TM3 mutations
MD Krasowski et al.
BRITISH JOURNAL OF PHARMACOLOGY (2000)
Effect of membrane lipid composition on the conformational equilibria of the nicotinic acetylcholine receptor
JE Baenziger et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Glycine receptors containing the alpha 4 subunit in the embryonic sympathetic nervous system, spinal cord and male genital ridge
RJ Harvey et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2000)
Treatment of fibromyalgia with tropisetron, a 5HT(3) serotonin antagonist: A pilot study
IA Papadopoulos et al.
CLINICAL RHEUMATOLOGY (2000)
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