4.6 Review

Thematic Review Series: Lipotoxicity: Many Roads to Cell Dysfunction and Cell Death Lipids, lysosomes, and autophagy

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Initiation and execution of lipotoxic ER stress in pancreatic β-cells

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A block of autophagy in lysosomal storage disorders

Carmine Settembre et al.

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FoxO3 controls autophagy in skeletal muscle in vivo

Cristina Mammucari et al.

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p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy

Serhiy Pankiv et al.

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Susmita Kaushik et al.

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Bax inhibition protects against free fatty acid-induced lysosomal permeabilization

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Lipotoxicity in the heart

NA Borradaile et al.

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Modulation of endosomal cholesteryl ester metabolism by membrane cholesterol

Y Wang et al.

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Genetic evidence for nonredundant functional cooperativity between NPC1 and NPC2 in lipid transport

DE Sleat et al.

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ME Guicciardi et al.

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Triglyceride accumulation protects against fatty acid-induced lipotoxicity

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