期刊
JOURNAL OF LIPID RESEARCH
卷 57, 期 4, 页码 697-705出版社
ELSEVIER
DOI: 10.1194/jlr.P066258
关键词
atherosclerosis; aortic stenosis; risk factor
资金
- EPIC-Norfolk Study
- Cancer Research UK [14136]
- Medical Research Council [G1000143]
- National Institutes of Health [R01 HL119828, P01 HL088093, P01 HL055798, R01 HL106579, R01 HL078610, R01 HL124174]
- British Heart Foundation [PG/08/094/26019] Funding Source: researchfish
- Cancer Research UK [14136] Funding Source: researchfish
- Medical Research Council [G0801566, G1000143, MC_PC_13048, MC_UU_12015/1, MC_U106179471] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0512-10114, NF-SI-0512-10135] Funding Source: researchfish
- MRC [G0801566, MC_UU_12015/1] Funding Source: UKRI
Variable agreement exists between different lipoprotein (a) [Lp(a)] measurement methods, but their clinical relevance remains unclear. The predictive value of Lp(a) measured by two different assays [Randox and University of California, San Diego (UCSD)] was determined in 623 coronary artery disease (CAD) cases and 948 controls in a case-control study within the EPIC-Norfolk Prospective Population Study. Participants were divided into sex-specific quintiles, and by Lp(a) <50 versus >= 50 mg/dl, which represents the 80th percentile in northern European subjects. Randox and UCSD Lp(a) levels were strongly correlated; Spearman's correlation coefficients for men, women, and sexes combined were 0.905, 0.915, and 0.909, respectively (P < 0.001 for each). The >80th percentile cutoff values, however, were 36 mg/dl and 24 mg/dl for the Randox and UCSD assays, respectively. Despite this, Lp(a) levels were significantly associated with CAD risk, with odds ratios of 2.18 (1.58-3.01) and 2.35 (1.70-3.26) for people in the top versus bottom Lp(a) quintile for the Randox and UCSD assays, respectively. This study demonstrates that CAD risk is present at lower Lp(a) levels than the currently suggested optimal Lp(a) level of <50 mg/dl. Appropriate thresholds may need to be population and assay specific until Lp(a) assays are standardized and Lp(a) thresholds are evaluated broadly across all populations at risk for CVD and aortic stenosis.
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