4.5 Review

Cancer stem cells in esophageal squamous cell carcinoma

期刊

PATHOLOGY RESEARCH AND PRACTICE
卷 237, 期 -, 页码 -

出版社

ELSEVIER GMBH
DOI: 10.1016/j.prp.2022.154043

关键词

Cancer stem cells; Esophageal squamous cell carcinoma; Therapeutic resistance

资金

  1. National Natural Science Foundation of China [82103522]
  2. China Postdoctoral Science Foundation [2021TQ0362]
  3. Key Research and Development Projects of Shaanxi Province [2022SF-029]

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This review discusses the importance of cancer stem cells (CSCs) in the diagnosis and treatment of esophageal squamous cell carcinoma (ESCC). It outlines the known methods for isolation and verification of CSCs, as well as the significance of CSCs' biomarkers and signaling pathways.
Esophageal squamous cell carcinoma (ESCC) is one of the most intractable challenges among human diseases with poor prognosis and shortness of effective therapeutic options. Cancer stem cells (CSCs), a tumor subpopulation, are considered the cause of tumor growth, differentiation, metastasis and therapeutic resistance, etc. In this review, we discuss the known methods for isolation and verification of ESCC CSCs, the biomarkers of ESCC CSCs and their significance in diagnosis and prognosis. Then we review the ESCC CSC signaling pathway and therapeutic resistance. In pace with the detailed studies of ESCC CSCs increasing, treatment strategies of ESCC based on CSCs are becoming more promising.

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