A potential biomarker of esophageal squamous cell carcinoma WTAP promotes the proliferation and migration of ESCC

This study focuses on the function of WTAP in esophageal squamous cell carcinoma (ESCC) samples and cell lines. The results showed that WTAP expression in ESCC tissues was significantly upregulated in 78.1% (57 of 73) of the ESCC tissues at the protein level compared with adjacent non-cancerous tissues via immunohistochemical staining. The WTAP protein expression level was positively correlated with the lymph node metastasis and TNM stage, and patients with higher WTAP protein expression level exhibited a shorter overall survival interval. Knocking down WTAP significantly reduced cell proliferation and migration but promoted cell apoptosis of TE-1and KYSE150 cells. Moreover, WTAP inhibition reduced the expression of ki67 and Snail related to cell pro-liferation and migration but increased the expression of Bax and Caspase-3 which were involved in cell apoptosis. In conclusion, our results suggest that the WTAP, a potential biomarker of ESCC, maybe play an important role in ESCC-genesis through regulating expression of genes related to cell proliferation, migration and apoptosis.

Automated summary

This study investigates the role of WTAP in esophageal squamous cell carcinoma (ESCC), finding that its expression is significantly upregulated in ESCC tissues and is correlated with lymph node metastasis, TNM stage, and overall survival. Knocking down WTAP inhibits cell proliferation and migration while promoting apoptosis, suggesting its involvement in ESCC-genesis.