期刊
PANCREATOLOGY
卷 22, 期 8, 页码 1091-1098出版社
ELSEVIER
DOI: 10.1016/j.pan.2022.10.004
关键词
Pancreatitis; Prevention; Natural history; Alcohol; Treatment
资金
- National Cancer Institute (NCI)
- National Institute of Diabetes And Digestive and Kidney Diseases (NIDDK)
- [DK061451]
- [DK077906]
- [U01DK108306]
- [U01 DK127377]
In a well-defined North American cohort, it was found that approximately 70.7% of patients with chronic pancreatitis had a history of acute pancreatitis, with the majority occurring more than 5 years prior to the diagnosis of chronic pancreatitis. Patients with multiple episodes of acute pancreatitis were diagnosed with chronic pancreatitis an average of 5 years earlier compared to those with only one episode.
Introduction: The mechanistic definition of chronic pancreatitis (CP) identifies acute pancreatitis (AP) as a precursor stage. We hypothesized that clinical AP frequently precedes the diagnosis of CP and is associated with patient-and disease-related factors. We describe the prevalence, temporal relationship and associations of AP in a well-defined North American cohort. Methods: We evaluated data from 883 patients with CP prospectively enrolled in the North American Pancreatitis Studies across 27 US centers between 2000 and 2014. We determined how often patients had one or more episodes of AP and its occurrence in relationship to the diagnosis of CP. We used multivariable logistic regression to determine associations for prior AP. Results: There were 624/883 (70.7%) patients with prior AP, among whom 161 (25.8%) had AP within 2 years, 115 (18.4%) within 3-5 years, and 348 (55.8%) >5 years prior to CP diagnosis. Among 504 AP patients with available information, 436 (86.5%) had >1 episode. On multivariable analyses, factors associated with increased odds of having prior AP were a younger age at CP diagnosis, white race, abdominal pain, pseudocyst(s) and pancreatic duct dilatation/stricture, while factors associated with a lower odds of having prior AP were exocrine insufficiency and pancreatic atrophy. When compared with patients with 1 episode, those with >1 AP episode were diagnosed with CP an average of 5 years earlier.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据