Integrated Analysis of Multiomics Data Identified Molecular Subtypes and Oxidative Stress-Related Prognostic Biomarkers in Glioblastoma Multiforme

Article Clinical Neurology

LGG-61. Cerebrospinal fluid as a source for liquid biopsy in pediatric gliomas

Liana Nobre et al.

NEURO-ONCOLOGY (2022)

Article Rheumatology

Early prediction of clinical response to anti-TNF treatment using multi-omics and machine learning in rheumatoid arthritis

Niyaz Yoosuf et al.

Summary: Our study identified new biomarkers for predicting response to anti-TNF treatment, revealed pathways affected by treatment, and proposed new predictive models for RA patients.

RHEUMATOLOGY (2022)

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Article Clinical Neurology

Simvastatin Inhibits Tumor Growth and Migration by Mediating Caspase-1-Dependent Pyroptosis in Glioblastoma Multiforme

Shulong Yang et al.

Summary: Simvastatin inhibits the progression of GBM by suppressing caspase-1-dependent pyroptosis, regulated by miR-214. Additionally, simvastatin decreases the viability of GBM cells and inhibits cell migration and invasion in a dose-dependent manner.

WORLD NEUROSURGERY (2022)

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Article Oncology

Targeting protein arginine methyltransferase 5 sensitizes glioblastoma to trametinib

Yeshavanth Kumar Banasavadi-Siddegowda et al.

Summary: The study demonstrated that combined inhibition of PRMT5 and MEK synergistically inhibited glioblastoma in animal models, showing promising therapeutic potential.

NEURO-ONCOLOGY ADVANCES (2022)

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Article Medicine, Research & Experimental

Stromal oncostatin M cytokine promotes breast cancer progression by reprogramming the tumor microenvironment

Angela M. Araujo et al.

Summary: This study reveals the pivotal role of the cytokine oncostatin M (OSM) in regulating interactions between immune and nonimmune stromal cells and epithelial cancer cells. It demonstrates that the stromal OSM/OSMR axis reprograms the tumor microenvironment and plays a key role in breast cancer progression.

JOURNAL OF CLINICAL INVESTIGATION (2022)

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Article Clinical Neurology

Simvastatin Inhibits Tumor Growth and Migration by Mediating Caspase-1-Dependent Pyroptosis in Glioblastoma Multiforme

Shulong Yang et al.

Summary: This study demonstrates that simvastatin can inhibit cell viability, migration, and invasion abilities of GBM, as well as suppress inflammatory pyroptosis. Through regulation by miR-214, simvastatin inhibits GBM progression by suppressing caspase-1-dependent inflammatory pyroptosis.

WORLD NEUROSURGERY (2022)

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Article Chemistry, Medicinal

Serum Extracellular Vesicle-Derived circHIPK3 and circSMARCA5 Are Two Novel Diagnostic Biomarkers for Glioblastoma Multiforme

Michele Stella et al.

Summary: The study suggests that sEV-derived circSMARCA5 and circHIPK3 are potential diagnostic biomarkers for GBM, especially when combined with preoperative NLR, PLR, and LMR to improve diagnostic accuracy.

PHARMACEUTICALS (2021)

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Article Plant Sciences

Feiyangchangweiyan capsule protects against ulcerative colitis in mice by modulating the OSM/OSMR pathway and improving gut microbiota

Yao Li et al.

Summary: The study demonstrated that FYC can significantly alleviate the pathological damage and inflammatory cell infiltration in the colon tissue of UC mice induced by dextran sulfate sodium, restore colon length, reduce DAI score, MPO content, pro-inflammatory factors, and increase anti-inflammatory factors. The protective effect of FYC on UC is achieved by inhibiting the OSM/OSMR pathway and regulating inflammatory factors to improve the intestinal flora.

PHYTOMEDICINE (2021)

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Article Pharmacology & Pharmacy

CXCR4 antagonism sensitizes cancer cells to novel indole-based MDM2/4 inhibitors in glioblastoma multiforme

Simona Daniele et al.

Summary: Glioblastoma multiforme (GBM) is characterized by high invasiveness, resistance to treatment, and poor survival, with abnormal p53 function, overexpression of MDM2/4, and involvement of the CXCR4 pathway. Inhibiting CXCR4/MDM2/4 shows promise in reducing GBM proliferation and invasion, including in cancer stem cell components.

EUROPEAN JOURNAL OF PHARMACOLOGY (2021)

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Article Oncology

Bioinformatics analysis of immune infiltration in glioblastoma multiforme based on data using a methylation chip in the GEO database

Song-Zhou Du et al.

Summary: The study utilized methylation data from a GEO database to investigate immune cell infiltration in glioblastoma patients. Results revealed significant individual differences between long-term and short-term survival groups, and no significant difference in the infiltration of immune cells between the two groups. The research highlights the potential for targeted therapy in GBM by studying immune infiltrating cells.

TRANSLATIONAL CANCER RESEARCH (2021)

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Article Oncology

CK2 Activity Mediates the Aggressive Molecular Signature of Glioblastoma Multiforme by Inducing Nerve/Glial Antigen (NG)2 Expression

Beate M. Schmitt et al.

Summary: The study found that the expression of nerve/glial antigen (NG)2 crucially determines the aggressiveness of glioblastoma multiforme (GBM), and that protein kinase CK2 regulates NG2 expression. Inhibition of CK2 significantly reduces proliferation and migration of NG2-positive GBM cells, and there is a positive correlation between the expression of CK2 and NG2 in GBM. The inhibition of CK2 with CX-4945 may represent a promising approach to suppress the aggressive molecular signature of NG2-positive GBM cells.

CANCERS (2021)

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Article Cardiac & Cardiovascular Systems

Common Variants Associated With OSMR Expression Contribute to Carotid Plaque Vulnerability, but Not to Cardiovascular Disease in Humans

Danielle van Keulen et al.

Summary: The study found that a genetic variant (rs1316887) in the OSMR locus is associated with increased plaque vulnerability, but not with coronary calcification or cardiovascular disease risk. The precise biological mechanisms through which OSM signaling affects plaque morphology remain unclear.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2021)

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Article Biology

Overexpression of Lipocalin-2 Inhibits Proliferation and Invasiveness of Human Glioblastoma Multiforme Cells by Activating ERK Targeting Cathepsin D Expression

Yi-Hsien Hsieh et al.

Summary: Lipocalin-2 (LCN2) has both pro- and anti-carcinogenic effects in various cancers, but its role in glioblastoma multiforme (GBM) progression is not fully understood. Overexpression of LCN2 was found to inhibit GBM cell proliferation and invasion through the activation of ERK-induced CTSD expression. LCN2 may serve as both a treatment strategy and prognostic marker for GBM.

BIOLOGY-BASEL (2021)

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Article Oncology

Extrinsic factors associated with the response to immunotherapy in glioblastoma

Hongye Bi et al.

Summary: Glioblastoma is a heterogeneous and lethal brain tumor that is largely refractory to immunotherapy. The immune microenvironment of GBM is highly immunosuppressive, affecting the efficacy of immunotherapy. Understanding the unique immune microenvironment of the brain and the impact of different immune and non-immune cells is crucial for improving the efficacy of immunotherapy.

CANCER LETTERS (2021)

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Article Integrative & Complementary Medicine

Highly Expressed CYBRD1 Associated with Glioma Recurrence Regulates the Immune Response of Glioma Cells to Interferon

Mingjie Qing et al.

Summary: The study identified increased expression of CYBRD1 in gliomas, which may be associated with unfavorable clinical outcomes and could potentially serve as a biomarker for glioma recurrence. CYBRD1 overexpression enhances glioma cell aggressiveness and attenuates the antitumor effects of IFN-alpha.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2021)

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Article Pathology

Comprehensive molecular and clinical characterization of SLC1A5 in human cancers

Han Zhang et al.

Summary: This study conducted a Pan-cancer analysis of SLC1A5 across 30 types of human cancers, revealing its upregulation in multiple cancers, particularly in digestive and respiratory system cancers, driven by CNV gain and DNA hypomethylation. The research also demonstrated that SLC1A5 overexpression is associated with tumor progression and poor survival in various cancers, with potential effects on cell functions and drug response.

PATHOLOGY RESEARCH AND PRACTICE (2021)

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Article Genetics & Heredity

A Missense Mutation in the MYBPH Gene Is Associated With Abdominal Fat Traits in Meat-Type Chickens

Priscila Anchieta Trevisoli et al.

Summary: The study aimed to identify predicted deleterious mutations affecting carcass traits in meat-type chickens and provided evidence that the c.482C > T SNP in the MYBPH gene may be a potential causal mutation for fat deposition.

FRONTIERS IN GENETICS (2021)

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Article Biochemistry & Molecular Biology

Misregulation of the expression and activity of DNA methyltransferases in cancer

Isaiah K. Mensah et al.

Summary: DNA methyltransferases play a crucial role in maintaining DNA methylation in mammalian cells, with mutations and abnormal expression affecting cell proliferation and identity in cancer. Aberrant DNA methylation is a hallmark of most cancers, and despite the effectiveness of DNMT inhibitors in some cases, their lack of specificity can lead to a range of deleterious effects. Understanding the distinct molecular mechanisms of DNMTs could help in identifying alternative cancer therapeutic targets.

NAR CANCER (2021)

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Article Biochemistry & Molecular Biology

IGFBP-3 and TGF-β inhibit growth in epithelial cells by stimulating type V TGF-β receptor (TβR-V)-mediated tumor suppressor signaling

Chun-Lin Chen et al.

Summary: The TGF-beta type V receptor mediates growth inhibition in epithelial cells by stimulating PP2A and PP1 activities, leading to dephosphorylation of pRb-related proteins and growth arrest.

FASEB BIOADVANCES (2021)

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Article Oncology

Novel mechanism for OSM-promoted extracellular matrix remodeling in breast cancer: LOXL2 upregulation and subsequent ECM alignment

Simion C. Dinca et al.

Summary: High co-expression of LOXL2 and OSM in IDC patients is associated with worse metastasis-free survival rates, while high levels of either individually are less impactful; LOXL2 expression is positively correlated with OSM/OSM receptor (OSMR) expression in IDC patients. Additionally, OSM-induced LOXL2 promotes an increase in ECM collagen I fiber crosslinking, leading to significant fiber alignment between cells and increased IDC cell invasion.

BREAST CANCER RESEARCH (2021)

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Review Pharmacology & Pharmacy