期刊
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
卷 2022, 期 -, 页码 -出版社
HINDAWI LTD
DOI: 10.1155/2022/4631983
关键词
-
类别
资金
- Expert Center of Innovative Health Food
- Institute of Scientific and Technological Research
- Science and Technology Research Institute, Chiang Mai University
- Functional Food Research Center for Well-Being, Chiang Mai University
- Chiang Mai University.
Oxidative stress and inflammation are important factors in dyslipidemia. The study found that consuming the RP jelly drink for 8 weeks significantly improved lipid profiles and oxidative stress, but had no significant impact on inflammation and glucose levels.
Oxidative stress and inflammation play key roles in the pathophysiology in the pathophysiology of dyslipidemia, which are positive risks that increase atherosclerosis leading to important healthcare problems. Therefore, we aimed to study the antioxidant, anti-inflammatory, and lipid-lowering effects of jelly drink containing polyphenol-rich roselle calyces extract and passion fruit juice with pulp concentrate (RP jelly drink) in comparison to a placebo jelly drink for 8 weeks. Forty-three adults with dyslipidemia were randomly assigned into two groups: the RP jelly drink group and the placebo group. Glucose, total cholesterol (TC) triglyceride (TG), low-density lipoprotein-cholesterol (LDL-C), high-density lipoprotein-cholesterol (HDL-C), oxidative stress biomarkers, inflammatory parameters, and monocyte chemotactic protein-1 (MCP-1) were measured with fasting blood samples at baseline, 4 weeks and 8 weeks of intervention. Results showed a significant decrease in LDL-C and TG, respectively, after 8 weeks of RP jelly drink consumption (LDL-C: 107.63 & PLUSMN;22.98 mg/dL; TG: 109.79 & PLUSMN;38.83 mg/dL) compared to baseline measurements (LDL-C: 128.43 & PLUSMN;32.74 mg/dL; TG: 132.33 & PLUSMN;75.11 mg/dL). These may be possible due to reduced inflammation and improvements in oxidative stress, as demonstrated by the reduction of tumor necrosis factor- (TNF-) alpha and malondialdehyde (MDA), and the enhancement of glutathione (GSH) after consuming the RP jelly drink for 8 weeks. However, no significant differences of treatment on glucose, total cholesterol, MCP-1, interleukin-6, and interleukin-10 were observed. In conclusion, daily consumption of RP jelly drink for 8 weeks resulted in significant improvement in lipid profiles in subjects with dyslipidemia. However, more research is needed to assess its nutritional and functional potential.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据