期刊
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
卷 2022, 期 -, 页码 -出版社
HINDAWI LTD
DOI: 10.1155/2022/5124553
关键词
-
类别
资金
- National Key Research and Development Project [2019YFF0301603]
- National Natural Science Foundation of China [81870280, 32071107]
- Shaanxi Nova Program [2021SF-067, 2021KJXX-21]
- Young Talent Fund in FourthMilitary Medical University, Chengdu Science Technology Bureau Project [2021-YF05-01625-SN]
- Chengdu HighLevel Key Clinical Specialty Construction Project
Iron is crucial in various biological processes, but its abnormal regulation and accumulation can contribute to pathological processes in cardiovascular diseases. This review summarizes the pathological roles of iron-related oxidative stress in cardiovascular diseases and highlights the potential effects and mechanisms of mitochondrial iron homeostasis and dysfunction in these diseases.
Iron is indispensable in numerous biologic processes, but abnormal iron regulation and accumulation is related to pathological processes in cardiovascular diseases. However, the underlying mechanisms still need to be further explored. Iron plays a key role in metal-catalyzed oxidative reactions that generate reactive oxygen species (ROS), which can cause oxidative stress. As the center for oxygen and iron utilization, mitochondria are vulnerable to damage from iron-induced oxidative stress and participate in processes involved in iron-related damage in cardiovascular disease, although the mechanism remains unclear. In this review, the pathological roles of iron-related oxidative stress in cardiovascular diseases are summarized, and the potential effects and mechanisms of mitochondrial iron homeostasis and dysfunction in these diseases are especially highlighted.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据