4.8 Article

Enantioselective Synthesis of Both Axially and Planar Chiral Ferrocenes via Axial-to-Planar Diastereoinduction

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ORGANIC LETTERS
卷 24, 期 40, 页码 7294-7299

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AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.2c02707

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  1. National Natural Science Foundation of China
  2. [NSF 21871115]
  3. [22171114]

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This study synthesized ferrocenes with planar chirality using palladium/chiral norbornene cooperative catalysis and axial-to-planar diastereoinduction. The chiral norbornene was used to control the aromatic axial chirality and induce the planar chirality of ferrocene through C(sp2)-H activation.
Ferrocenes with planar chirality have emerged as an important class of scaffolds for ligands in asymmetric catalysis; however, ferrocene molecules with polychiral structures have not been well explored. Herein, both axially and planar chiral ferrocenes were synthesized via palladium/chiral norbornene cooperative catalysis and axial-to-planar diastereoinduction. In this work, chiral norbornene was used to stereoselectively control the aromatic axial chirality, and further selectivity induced C(sp2)-H activation for ferrocene planar chirality. Based on density functional theory calculations, the catalytic model of chiral norbornene with the substrate and the axial-to-planar diastereoinduction process were confirmed.

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