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AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.2c03410
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资金
- Natural Science Foundation of Chongqing, China [cstc2020jcyjmsxmX0130]
- Venture & Innovation Support Program for Chongqing Overseas Returnees [cx2021015, cx2018085]
- National Natural Science Foundation of China [21801209, 21801210]
This study presents a ruthenium-catalyzed intra-molecular aryl migrative isomerization, providing a mild and environmentally friendly method for synthesizing ketones with high step-and atom-economy and broad substrate scope. Additionally, the researchers discovered a heuristic paradigm for transition-metal-catalyzed C-C activation.
The isomerization of allylic alcohols to the corresponding carbonyl compounds is a well-established reaction in organic synthesis. However, 1,3-carbon migration is a quite challenging field, and thus transformation has remained elusive until now. Herein, we present the ruthenium-catalyzed intra-molecular 1,3-aryl migrative isomerization, which provides a mild and environmentally friendly method to synthesize various ketones with high step-and atom-economy and broad substrate scope. Meanwhile, the Ru(III)-catalyzed C(sp3)-C(aryl) bond cleavage of unactivated allylic alcohols may serve as a heuristic paradigm for transition-metal-catalyzed C-C activation.
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