期刊
ORGANIC LETTERS
卷 24, 期 41, 页码 7649-7653出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.2c03147
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-
资金
- Ministry of Science and Technology, Taiwan [MOST109-2113-M-002-010-MY2]
The study revealed that in the presence of Pd catalyst and DBU, (Z)-pent-2-en-4-yn-1-yl alkanoates can undergo acyl migration to yield high yields of 2-(alkanoylmethyl)furan derivatives, followed by oxidative decarbonylation with O2 to form 2-acylfurans. The mechanistic pathway involving intramolecular cyclization and acyl group shift was discussed.
Palladium-promoted acyl migration was observed in the reaction of (Z)-pent-2-en-4-yn-1-yl alkanoates in the presence of DBU to yield 2-(alkanoylmethyl)furan derivatives specialIntscript in high yields. Compounds 2 then underwent oxidative decarbonylation to afford 2-acylfurans with O2 as the oxidant under mild and metal-free conditions. The mechanistic pathway of the reaction involving an intramolecular cyclization and acyl group shift is discussed.
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