期刊
ORGANIC LETTERS
卷 24, 期 40, 页码 7421-7427出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.2c02993
关键词
-
资金
- IISER Pune
- Science and Engineering Research Board (SERB) New Delhi
- [EMR/2016/007601]
Replacing alpha(CH2) with NH in monomers of standard aeg PNA and its homologue beta-ala PNA leads to aza-PNA monomers, which can form either an 8-membered H-bonded ring or a 5-membered N alpha H-alpha CO bond to stabilize E-type rotamers. These aza-PNA oligomers with exclusive E rotamers and intraresidue backbone H-bonding can modulate their DNA/RNA binding and assembling properties.
The replacement of alpha(CH2) by NH in monomers of standard aeg PNA and its homologue beta-ala PNA leads to respective aza-PNA monomers (1 and 2) in which the N alpha H can form either an 8-membered H-bonded ring with folding of the backbone (DMSO and water) or a 5-membered N alpha H-alpha CO (water) to stabilize E-type rotamers. Such aza-PNA oligomers with exclusive E rotamers and intraresidue backbone H-bonding can modulate its DNA/RNA binding and assembling properties.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据