期刊
ORGANIC LETTERS
卷 24, 期 37, 页码 6789-6793出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.2c02666
关键词
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资金
- National Natural Science Foundation of China [81773901]
- Postgraduate Research & Practice Innovation Program of Jiangsu Province [KYCX18-0822]
- Syngenta Ph.D. Fellowship
Epicoccanes A-D are four novel metabolites isolated from an endophytic fungus, Epicoccum nigrum. They possess distinct structures and potential antiliver fibrosis activity.
Epicoccanes A-D (1-4) are four novel metabolites of an endophytic fungus Epicoccum nigrum. Their distinct unprecedented structures are hypothesized as oxidative dimers of pyrogallol analogues. Compounds 1 and 2 possess a novel spirobicyclo[3.2.1]octane-6,1'-cyclopentane or -cyclohexane core skeleton. Compound 3 is of a unique cage-like pentacyclic system, which unusually contained three continuous spiro-carbons. Compound 4 is a highly rearranged dimer with five contiguous chiral centers. The absolute structures of 1 and 2 were deduced by electronic circular dichroism (ECD) calculations, and those of 3 and 4 were determined by X-ray crystallography. Compounds 1 and 4 showed potential antiliver fibrosis activity.
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