期刊
ORGANIC LETTERS
卷 24, 期 43, 页码 7924-7927出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.2c02996
关键词
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资金
- EPSRC [EP/P026990/1]
- Royal Thai Government
A library of thiazoles and selenothiazoles were synthesized via Ir-catalyzed ylide insertion chemistry. This process is tolerant to functional groups and heterocycle substituents, making it applicable for the synthesis of anti-inflammatory drugs and enzyme-binding compounds in bacteria.
A library of thiazoles and selenothiazoles were synthesized via Ir-catalyzed ylide insertion chemistry. This process is a functional group, particularly heterocycle-substituent tolerant. This was applied to the synthesis of fanetizole, an anti-inflammatory drug, and a thiazole-containing drug fragment that binds to the peptidyl-tRNA hydrolase (Pth) in Neisseria gonorrheae bacteria.
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