期刊
ORGANIC LETTERS
卷 24, 期 46, 页码 8476-8480出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.2c03215
关键词
-
资金
- project OPENSCREEN-GR - Operational Program Competitiveness, Entrepreneurship and Innovation (NSRF 2014-2020) [MIS 5002691]
- European Union (European Regional Development Fund)
In this study, the oxy-Cope/ene reaction cascade was used to form a locked elemane conformer, enabling the short and scalable synthesis of versatile Apiaceae scaffolds. The divergent fate of the obtained macrocyclic germacrane was explored under different reaction conditions, leading to the diastereoselective synthesis of oxidized Apiaceae guaiane congeners and the total synthesis of 4-epi-epiguaidiol A. Additionally, the reduction of a hydrogen-bond-biased guaiane substrate allowed for the chemoselective synthesis of desoxo-jungiaguaiane.
The oxy-Cope/ene reaction cascade to form a locked elemane conformer allows the short scalable synthesis of versatile Apiaceae scaffolds. The divergent fate of the obtained macrocyclic germacrane is surveyed under cationic and dioxygeninduced Prins-type reaction conditions to allow the diastereoselective synthesis of oxidized Apiaceae guaiane congeners and the total synthesis of 4-epi-epiguaidiol A. Additionally, the unprecedented reduction of a hydrogen-bond-biased guaiane substrate permits the chemoselective synthesis of desoxo-jungiaguaiane.
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