期刊
ORGANIC LETTERS
卷 24, 期 41, 页码 7611-7616出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.2c03073
关键词
-
资金
- National Key Research and Develop- ment Program of China
- National Natural Science Foundation of China
- Science and Technology Commission of Shanghai Municipality
- [2021YFF0701700]
- [21971252]
- [21991122]
- [22271181]
- [22ZR1423600]
Here, we report the design and synthesis of a difluoromethylsulfonyl imidazolium salt, which serves as a radical difluoromethylation reagent for achieving amino- and oxy-difluoromethylation of alkenes. Importantly, the synthesis of the imidazolium salt can be accomplished without the need for distillation or column chromatography purification, and the amino- and oxy-difluoromethylation pathways are determined by the choice of reaction solvents.
Herein, we describe the design and synthesis of a difluoromethylsulfonyl imidazolium salt, which can act as a radical difluoromethylation reagent to achieve the challenging amino-and oxy-difluoromethylation of alkenes. Notably, the three steps for the synthesis of the imidazolium salt do not require any tedious distillation or column chromatography purification process, and the amino-and oxy-difluoromethylation paths are simply determined by the selection of reaction solvents.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据