期刊
ORGANIC LETTERS
卷 24, 期 39, 页码 7194-7199出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.2c02947
关键词
-
资金
- Daiko Foundation, Japan [9226]
We describe the development of a reliable catalytic protocol for peptide bond formation that is generally applicable to natural and unnatural alpha-amino acids, beta-amino acids, and peptides bearing various functional groups. A 10 mol % loading of HSi[OCH(CF3)(2)](3) as a catalyst was sufficient to guarantee a consistently high yield of the resulting peptide. This method facilitates the sustainable utilization of natural resources by using a catalyst and an auxiliary based on earth-abundant silicon.
We describe the development of a reliable catalytic protocol for peptide bond formation that is generally applicable to natural and unnatural alpha-amino acids, beta-amino acids, and peptides bearing various functional groups. A 10 mol % loading of HSi[OCH(CF3)(2)](3) as a catalyst was sufficient to guarantee a consistently high yield of the resulting peptide. This method facilitates the sustainable utilization of natural resources by using a catalyst and an auxiliary based on earth-abundant silicon.
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