期刊
ORGANIC LETTERS
卷 -, 期 -, 页码 -出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.2c02655
关键词
-
资金
- NSFC [22171196, 21801179]
- Sichuan Science and Technology Program [2021ZYD0054, 2022JDJQ0013]
The cascade reaction of Ir-catalyzed enantioselective allylic amination and Cu-catalyzed alkyne-azide cycloaddition allows for the efficient synthesis of enantioenriched homoallylic amidines.
The cascade of Ir-catalyzed enantioselective allylic amination and Cu-catalyzed alkyne-azide cycloaddition was designed for the asymmetric synthesis of homoallylic amidines. The nucleophilic addition of an in situ-generated enantioenriched tertiary allylamine to a ketenimine intermediate triggers a rapid and stereospecific zwitterionic aza-Claisen rearrangement in a 1,3 -chiral transfer manner. The approach allows modular access to enantioenriched alpha-chiral homoallylic amidines in high yields with a high level of enantiomeric purity.
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