期刊
ORGANIC LETTERS
卷 24, 期 37, 页码 6740-6744出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.2c02508
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资金
- National Institutes of Health [R01AG066223]
- MRI program by the National Science Foundation [1919565]
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [1919565] Funding Source: National Science Foundation
This study reports a Rh(III)-catalyzed C-H activation/annulation using an imidazolone as an alkene partner to access dihydroisoquinolone-fused imidazolin-2-ones. These compounds resemble the scaffolds found in the pyrrole alkaloid family of natural products. The method allows for the construction of various urea-fused dihydroisoquinolone scaffolds, including heterocyclic moieties.
A Rh(III)-catalyzed C-H activation/annulation with an imidazolone as alkene partner is reported to access dihydroisoquinolone-fused imidazolin-2-ones. These bicycles are reminiscent of scaffolds belonging to the pyrrole alkaloid family of natural products. This approach facilitates construction of a variety of urea-fused dihydroisoquinolone scaffolds including heterocyclic moieties.
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