Rh(III)-Catalyzed C-H Activation/Annulation of Benzohydroxamates and 2-Imidazolones: Access to Urea-Fused-Dihydroisoquinolone Scaffolds Reminiscent of Pyrrole Alkaloid Natural Products

A Rh(III)-catalyzed C-H activation/annulation with an imidazolone as alkene partner is reported to access dihydroisoquinolone-fused imidazolin-2-ones. These bicycles are reminiscent of scaffolds belonging to the pyrrole alkaloid family of natural products. This approach facilitates construction of a variety of urea-fused dihydroisoquinolone scaffolds including heterocyclic moieties.

Automated summary

This study reports a Rh(III)-catalyzed C-H activation/annulation using an imidazolone as an alkene partner to access dihydroisoquinolone-fused imidazolin-2-ones. These compounds resemble the scaffolds found in the pyrrole alkaloid family of natural products. The method allows for the construction of various urea-fused dihydroisoquinolone scaffolds, including heterocyclic moieties.