Total Synthesis of (+)-Gilbertine: A Cyclopentanone-Based Approach

From methyl jasmonate, the concise asymmetric total synthesis of uleine alkaloid gilbertine was reported. The synthesis demonstrated the power of a cyclopentanone-based approach involving the coupling of 2-aminobenzaldehyde and diazo-cyclopentanone for the rapid assembly of the hydrocarbazole natural product. methyl

Automated summary

This article reported the concise asymmetric total synthesis of gilbertine alkaloid from methyl jasmonate, using a cyclopentanone-based approach for the rapid assembly of the hydrocarbazole natural product.