Omega-3 polyunsaturated fatty acids inhibit cardiomyocyte apoptosis and attenuate sepsis-induced cardiomyopathy

Objectives: Sepsis can cause myocardial injury, which is one of the leading causes of death in critically ill patients. Fish oil rich in omega-3 polyunsaturated fatty acids (PUFAs) in ultralong chains has immunomodu-latory effects and can inhibit the production of various critically ill proinflammatory cytokines. Therefore, this study focused on whether v-3 PUFAs have a protective effect on sepsis-induced cardiomyopathy (SIC). Methods: Male 6-8 weeks old C57BL/6 mice were pretreated with 3% special fish oil supplement rat food for seven consecutive days prior to surgery. Cecal ligation and puncture (CLP) was perfromed to induce polymi-crobial sepsis.The cardiac function was assessed by echocardiography, apoptosis of cardiomyocyte were detected by TUNEL assay and Western blotting, and the level of TNF-a, IL-6, and IL-1b in plasma was deter-mined 24h after CLP. Results: Pretreatment with omega-3 PUFAs attenuated cardiomyocyte apoptosis, decreased the production of proinflammatory cytokines, attenuated the SIC, and improved the survival rate of septic mice induced by CLP. Conclusions: v-3 PUFAs alleviate SIC through attenuating cardiomyocyte apoptosis, which provides a new direction for the prevention and treatment of SIC. ?? 2022 Elsevier Inc. All rights reserved.

Automated summary

This study aimed to investigate whether omega-3 polyunsaturated fatty acids (PUFAs) have a protective effect on sepsis-induced cardiomyopathy (SIC). The findings showed that pretreatment with omega-3 PUFAs can attenuate cardiomyocyte apoptosis, reduce the production of proinflammatory cytokines, improve SIC, and increase the survival rate of septic mice.