期刊
NUTRITION
卷 106, 期 -, 页码 -出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.nut.2022.111880
关键词
Cancer cachexia; Palliative care team; Prognostic indices; Skeletal muscle mass; SARC-F
This study aimed to validate the cachexia staging score (CSS) as a diagnostic method for measuring cachexia severity in patients with advanced cancer receiving palliative care. The results showed that as the severity of cachexia increased, patients had shorter survival and experienced changes in symptoms and biomarkers associated with cachexia.
Objective: The aim of this study was to validate the cachexia staging score (CSS), a multidimensional, item -based diagnostic method of cachexia severity, for patients with advanced cancer receiving palliative care. Methods: Eligible patients were those with cancer who received palliative care during hospitalization between May 2019 and April 2020. All data were collected retrospectively from medical records. Cachexia was graded into four levels according to the CSS. Kaplan-Meier curves were constructed with or without death as the outcome, comparing prognoses among different levels of cachexia with Bonferroni correction. Cox proportional hazards regression analysis was performed to identify factors affecting mortality. Results: The mean age of the 196 patients was 65.8 +/- 14 y. Men made up 42% of the study population. Lower body mass index, increased rate of weight loss, increased strength, assistance walking, rising from a chair, climbing stairs, and falls (SARC-F) points, decline in activities of daily living, appetite loss, and abnormal blood biomarkers were significantly more common with increasing severity of cachexia, and survival was shorter (P < 0.001). The hazard ratio (HR) increased with worsening severity of cachexia according to CSS classification (precachexia: HR, 2.78; 95% confidence interval [CI], 0.62-12.46, P = 0.182; cachexia: HR, 4.77; 95% CI, 1.09-20.80; P = 0.038; and refractory cachexia: HR, 11.00; 95% CI, 2.37-51.07; P = 0.002). Conclusions: The CSS predicted life expectancy in a population of patients receiving palliative care and had excellent prognostic discriminative power to classify patients at different stages of cachexia. (c) 2022 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据