期刊
JOURNAL OF LEUKOCYTE BIOLOGY
卷 101, 期 1, 页码 307-320出版社
OXFORD UNIV PRESS
DOI: 10.1189/jlb.3A0216-082R
关键词
transfer factor; cellular immunity; Tc17
资金
- Intramural Research Program of NIAID
- U.S. National Institutes of Health
Cellular lysates from PPD+ donors have been reported to transfer tuberculin reactivity to naive recipients, but not diphtheria reactivity, and vice versa. A historically controversial topic, the terms transfer factor and DLE were used to characterize the reactivity-transferring properties of lysates. Intrigued by these reported phenomena, we found that the cellular extract derived from antigen-specific memory CD8(+) T cells induces IL-6 from antigen-matched APCs. This ultimately elicits IL-17 from bystander memory CD8(+) T cells. We have identified that dialyzable peptide sequences, S100a9, and the TCR beta chain from CD8(+) T cells contribute to the molecular nature of this activity. We further show that extracts from antigen-targeted T cells enhance immunity to Staphylococcus aureus and Candida albicans. These effects are sensitive to immunization protocols and extraction methodology in ways that may explain past discrepancies in the reproducibility of passive cellular immunity.
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