Nirmatrelvir Use and Severe Covid-19 Outcomes during the Omicron Surge

Article Pharmacology & Pharmacy

Remdesivir, Molnupiravir and Nirmatrelvir remain active against SARS-CoV-2 Omicron and other variants of concern

Laura Vangeel et al.

Summary: Remdesivir and its parent nucleoside, molnupiravir and its parent nucleoside, and the viral protease inhibitor nirmatrelvir have equipotent antiviral activity against the ancestral SARS-CoV2 strain and the variants of concern including Omicron.

ANTIVIRAL RESEARCH (2022)

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Letter Cell Biology

SARS-CoV-2 Omicron variant is highly sensitive to molnupiravir, nirmatrelvir, and the combination

Pengfei Li et al.

CELL RESEARCH (2022)

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Editorial Material Medicine, General & Internal

Audio Interview: Understanding the Omicron Variant of SARS-CoV-2

Eric J. Rubin et al.

NEW ENGLAND JOURNAL OF MEDICINE (2022)

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Letter Medicine, General & Internal

Efficacy of Antibodies and Antiviral Drugs against Covid-19 Omicron Variant

Emi Takashita et al.

NEW ENGLAND JOURNAL OF MEDICINE (2022)

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Article Medicine, General & Internal

Oral Nirmatrelvir for High-Risk, Nonhospitalized Adults with Covid-19

Jennifer Hammond et al.

Summary: In high-risk, unvaccinated adults, treatment of Covid-19 with nirmatrelvir plus ritonavir can significantly reduce the risk of hospitalization and death, with good safety profile.

NEW ENGLAND JOURNAL OF MEDICINE (2022)

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Editorial Material Medicine, General & Internal

The Potential of Intentional Drug Development

Eric J. Rubin et al.

Summary: At the onset of the Covid-19 pandemic, there were high hopes for swift interventions to mitigate the severity of the disease and save lives. While several drugs, both approved and under investigation, displayed in vitro activity against the causative virus SARS-CoV-2, many repurposed medications did not demonstrate meaningful clinical efficacy against Covid. Two investigational agents, remdesivir and molnupiravir, eventually exhibited some clinical effectiveness, albeit with notable drawbacks.

NEW ENGLAND JOURNAL OF MEDICINE (2022)

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Article Biochemistry & Molecular Biology

Effectiveness of a second BNT162b2 booster vaccine against hospitalization and death from COVID-19 in adults aged over 60 years

Ronen Arbel et al.

Summary: A retrospective analysis of data from Israel shows that a second booster shot of BNT162b2 in individuals aged 60 and over significantly reduces hospitalizations and deaths due to COVID-19.

NATURE MEDICINE (2022)

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Letter Medicine, General & Internal

Efficacy of Antiviral Agents against the SARS-CoV-2 Omicron Subvariant BA.2

Emi Takashita et al.

NEW ENGLAND JOURNAL OF MEDICINE (2022)

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Article Medicine, General & Internal

BNT162b2 Vaccine Booster and Mortality Due to Covid-19

Ronen Arbel et al.

Summary: Among 843,208 participants in Israel aged 50 years or older who had received two doses of the BNT162b2 vaccine at least 5 months earlier, those who received a booster had 90% lower mortality due to Covid-19 than those who did not receive a booster during the 54-day study period.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Medicine, General & Internal

BNT162b2 mRNA Covid-19 Vaccine in a Nationwide Mass Vaccination Setting

Noa Dagan et al.

Summary: A study conducted in Israel on nearly 600,000 individuals showed that the BNT162b2 mRNA vaccine was effective in reducing the risk of infection, hospitalization, and severe Covid-19. The effectiveness in preventing death was 72% during the period from day 14 through day 20 after the first dose, and hospitalization was reduced by 87% for the period 7 or more days after the second dose, similar to results from a randomized trial.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Medicine, General & Internal

Problem of immortal time bias in cohort studies: example using statins for preventing progression of diabetes

Linda E. Levesque et al.

BRITISH MEDICAL JOURNAL (2010)

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Nirmatrelvir Use and Severe Covid-19 Outcomes during the Omicron Surge

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