期刊
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
卷 140, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neubiorev.2022.104765
关键词
Targeted memory reactivation (TMR); PTSD; Sleep; Memory consolidation; Treatment
资金
- Netherlands Organi- sation for Scientific Research, The Netherlands: Innovational Research Incentives Scheme Veni Research [016.176.130]
- Netherlands Organisation for Health Research and Development, The Netherlands [91215209]
- Brain & Behavior Research Foundation, United States of America [27771]
- EMDR Research Foundation, The Netherlands
This article reviews the potential of targeted memory reactivation (TMR) as a new sleep-based treatment for post-traumatic stress disorder (PTSD). It provides background information on the memory and sleep principles underlying PTSD, as well as the current applications and conditional factors of TMR. The outstanding questions and most promising experimental avenues for testing TMR to treat traumatic memories are also discussed.
Post-traumatic stress disorder (PTSD) is a severe psychiatric disorder in which traumatic memories result in flashbacks and nightmares. With one-third of patients not responding to standard exposure-based psychotherapy, new treatment strategies are needed. Sleep offers a unique time window to enhance therapeutic efficacy. Traumatic memories that are neutralized in therapy need to be stored back into memory (consolidated) during sleep to solidify the treatment effect. New basic research shows that memory consolidation can be enhanced by presenting sounds or scents that were linked to the memory at encoding, again during sleep. This procedure, termed targeted memory reactivation (TMR), has, despite its clinical potential, not been tested in (PTSD) patients. In this narrative review, we explore the potential of TMR as a new sleep-based treatment for PTSD. First we provide the necessary background on the memory and sleep principles underlying PTSD as well as the present applications and conditional factors of TMR. Then, we will discuss the outstanding questions and most promising experimental avenues when testing TMR to treat traumatic memories.
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