Remembering the pattern: A longitudinal case study on statistical learning in spatial navigation and memory consolidation

Distinct brain systems are thought to support statistical learning over different timescales. Regularities encountered during online perceptual experience can be acquired rapidly by the hippocampus. Further pro-cessing during offline consolidation can establish these regularities gradually in cortical regions, including the medial prefrontal cortex (mPFC). These mechanisms of statistical learning may be critical during spatial navi-gation, for which knowledge of the structure of an environment can facilitate future behavior. Rapid acquisition and prolonged retention of regularities have been investigated in isolation, but how they interact in the context of spatial navigation is unknown. We had the rare opportunity to study the brain systems underlying both rapid and gradual timescales of statistical learning using intracranial electroencephalography (iEEG) longitudinally in the same patient over a period of three weeks. As hypothesized, spatial patterns were represented in the hip-pocampus but not mPFC for up to one week after statistical learning and then represented in the mPFC but not hippocampus two and three weeks after statistical learning. Taken together, these findings suggest that the hippocampus may contribute to the initial extraction of regularities prior to cortical consolidation.

Automated summary

The study found that in spatial navigation, the hippocampus may contribute to the initial extraction of regularities before cortical consolidation, while the mPFC gradually represents these regularities during the consolidation process.