期刊
NEURON
卷 110, 期 17, 页码 2728-2742出版社
CELL PRESS
DOI: 10.1016/j.neuron.2022.07.018
关键词
-
资金
- Wellcome [219627/Z/19/Z]
- Wellcome Investigator Award [219561/Z/19/Z]
- Gatsby Charitable Foundation
- Wellcome Trust [219561/Z/19/Z, 219627/Z/19/Z] Funding Source: Wellcome Trust
Prethalamic nuclei in the mammalian brain play a crucial role in influencing brain functions and behaviors, including sleep, feeding, and exploration. These nuclei integrate sensory and non-sensory information and promote specific behavioral strategies by modulating inhibitory drive onto different target areas.
Prethalamic nuclei in the mammalian brain include the zona incerta, the ventral lateral geniculate nucleus, and the intergeniculate leaflet, which provide long-range inhibition to many targets in the midbrain, hindbrain, and thalamus. These nuclei in the caudal prethalamus can integrate sensory and non-sensory information, and together they exert powerful inhibitory control over a wide range of brain functions and behaviors that encompass most aspects of the behavioral repertoire of mammals, including sleep, circadian rhythms, feeding, drinking, predator avoidance, and exploration. In this perspective, we highlight the evidence for this wide-ranging control and lay out the hypothesis that one role of caudal prethalamic nuclei may be that of a behavioral switchboard that-depending on the sensory input, the behavioral context, and the state of the animal-can promote a behavioral strategy and suppress alternative, competing behaviors by modu-lating inhibitory drive onto diverse target areas.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据