期刊
NEUROIMAGE
卷 263, 期 -, 页码 -出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2022.119640
关键词
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资金
- NIH/NIHM [R01MH111444, DP1 NS116783]
- NIH [S10 OD025176]
- NIH/NINDS [R01 AG064051]
- NIH/NIA [R01 EB030884]
- NIH/NIBIB
- [RF1 MH114227]
This study investigates the circuitry of different layers within the primary motor cortex and reveals distinct responses in the brain when stimulating different layers. These findings contribute to a better understanding of how the primary motor cortex is embedded in the brain-wide circuitry.
Primary motor cortex (M1) consists of a stack of interconnected but distinct layers (L1-L6) which affect motor control through large-scale networks. However, the brain-wide functional influence of each layer is poorly understood. We sought to expand our knowledge of these layers' circuitry by combining Cre-driver mouse lines, optogenetics, fMRI, and electrophysiology. Neuronal activities initiated in Drd3 neurons (within L2/3) were mainly confined within M1, while stimulation of Scnn1a, Rbp4, and Ntsr1 neurons (within L4, L5, and L6, respectively) evoked distinct responses in M1 and motor-related subcortical regions, including striatum and motor thalamus. We also found that fMRI responses from targeted stimulations correlated with both local field potentials (LFPs) and spike changes. This study represents a step forward in our understanding of how different layers of primary motor cortex are embedded in brain-wide circuitry.
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