期刊
NEUROBIOLOGY OF DISEASE
卷 172, 期 -, 页码 -出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.nbd.2022.105815
关键词
Dopamine; Parkinson's disease; SNc; Striatum; Inhibition; Basal ganglia; Dendrites; Disinhibition; Circuit mapping; Dendritic morphology; Substantia nigra; Striatonigral; Nigrostriatal
资金
- BRAIN initiative NIH grant [R00NS112417]
- APDA grant [2021APDA00RG00000209666-R13]
This paper reviews foundational studies and recent work comparing the circuitry of the ventral and dorsal SNc neurons, discussing how loss of ventral neurons early in Parkinson's Disease could affect the overall balance of inhibition and disinhibition of dopamine signals.
Dopaminergic neurons in the substantia nigra pars compacta (SNc) differentially degenerate in Parkinson's Disease, with the ventral region degenerating more severely than the dorsal region. Compared with the dorsal neurons, the ventral neurons in the SNc have distinct dendritic morphology, electrophysiological characteristics, and circuit connections with the basal ganglia. These characteristics shape information processing in the ventral SNc and structure the balance of inhibition and disinhibition in the striatonigral circuitry. In this paper, I review foundational studies and recent work comparing the circuitry of the ventral and dorsal SNc neurons and discuss how loss of the ventral neurons early in Parkinson's Disease could affect the overall balance of inhibition and disinhibition of dopamine signals.
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