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PINK1 Heterozygous Mutations Induce Subtle Alterations in Dopamine-Dependent Synaptic Plasticity
Graziella Madeo et al.
MOVEMENT DISORDERS (2014)
Lazy Nigrostriatal Synapses in the Heterozygous PINK1 Mouse Model of Familial Parkinson's Disease
Paolo Calabresi et al.
MOVEMENT DISORDERS (2014)
LRRK2 regulates synaptogenesis and dopamine receptor activation through modulation of PKA activity
Loukia Parisiadou et al.
NATURE NEUROSCIENCE (2014)
Region-specific deficits in dopamine, but not norepinephrine, signaling in a novel A30P α-synuclein BAC transgenic mouse
Tonya N. Taylor et al.
NEUROBIOLOGY OF DISEASE (2014)
(G2019S) LRRK2 causes early-phase dysfunction of SNpc dopaminergic neurons and impairment of corticostriatal long-term depression in the PD transgenic mouse
Jun-Shiao Chou et al.
NEUROBIOLOGY OF DISEASE (2014)
Region specific mitochondrial impairment in mice with widespread overexpression of alpha-synuclein
Sudhakar Raja Subramaniam et al.
NEUROBIOLOGY OF DISEASE (2014)
Phenotypic characterization of recessive gene knockout rat models of Parkinson's disease
Kuldip D. Dave et al.
NEUROBIOLOGY OF DISEASE (2014)
Unaltered Striatal Dopamine Release Levels in Young Parkin Knockout, Pink1 Knockout, DJ-1 Knockout and LRRK2 R1441G Transgenic Mice
Gonzalo Sanchez et al.
PLOS ONE (2014)
Synaptic function is modulated by LRRK2 and glutamate release is increased in cortical neurons of G2019S LRRK2 knock-in mice
Dayne A. Beccano-Kelly et al.
FRONTIERS IN CELLULAR NEUROSCIENCE (2014)
iPSC-derived neurons from GBA1-associated Parkinson's disease patients show autophagic defects and impaired calcium homeostasis
David C. Schoendorf et al.
NATURE COMMUNICATIONS (2014)
Parkinson's disease: animal models and dopaminergic cell vulnerability
Javier Blesa et al.
FRONTIERS IN NEUROANATOMY (2014)
Defective quality control mechanisms and accumulation of damaged mitochondria link Gaucher and Parkinson diseases
Laura D. Osellame et al.
AUTOPHAGY (2013)
PINK1 protects against cell death induced by mitochondrial depolarization, by phosphorylating Bcl-xL and impairing its pro-apoptotic cleavage
G. Arena et al.
CELL DEATH AND DIFFERENTIATION (2013)
Effect of quercetin and desferrioxamine on 6-hydroxydopamine (6-OHDA) induced neurotoxicity in striatum of rats
Nagaraja Haleagrahara et al.
JOURNAL OF TOXICOLOGICAL SCIENCES (2013)
Animal Models of Parkinson's Disease: Limits and Relevance to Neuroprotection Studies
Erwan Bezard et al.
MOVEMENT DISORDERS (2013)
Advances in the genetics of Parkinson disease
Joanne Trinh et al.
NATURE REVIEWS NEUROLOGY (2013)
Mitochondrial dysfunction and oxidative stress in Parkinson's disease and monogenic parkinsonism
David N. Hauser et al.
NEUROBIOLOGY OF DISEASE (2013)
Glucocerebrosidase inhibition causes mitochondrial dysfunction and free radical damage
Michael W. J. Cleeter et al.
NEUROCHEMISTRY INTERNATIONAL (2013)
Genetics of Parkinson's disease: the yield
Marianna Spatola et al.
PARKINSONISM & RELATED DISORDERS (2013)
Short- and Long-Term Effects of LRRK2 on Axon and Dendrite Growth
Bryan Sepulveda et al.
PLOS ONE (2013)
Non-Motor and Motor Features in LRRK2 Transgenic Mice
Zoe Bichler et al.
PLOS ONE (2013)
Deficits in dopaminergic transmission precede neuron loss and dysfunction in a new Parkinson model
Stephanie Janezic et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Large α-synuclein oligomers inhibit neuronal SNARE-mediated vesicle docking
Bong-Kyu Choi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Motile Axonal Mitochondria Contribute to the Variability of Presynaptic Strength
Tao Sun et al.
CELL REPORTS (2013)
Glucocerebrosidase deficiency in substantia nigra of parkinson disease brains
Matthew E. Gegg et al.
ANNALS OF NEUROLOGY (2012)
Toxin Models of Mitochondrial Dysfunction in Parkinson's Disease
Terina N. Martinez et al.
ANTIOXIDANTS & REDOX SIGNALING (2012)
The neurobiology of glucocerebrosidase-associated parkinsonism: a positron emission tomography study of dopamine synthesis and regional cerebral blood flow
Ozlem Goker-Alpan et al.
BRAIN (2012)
Animal models of Parkinson's disease
Fabio Blandini et al.
FEBS JOURNAL (2012)
Nuclear translocation of DJ-1 during oxidative stress-induced neuronal cell death
Su-Jeong Kim et al.
FREE RADICAL BIOLOGY AND MEDICINE (2012)
Using genome-wide complex trait analysis to quantify 'missing heritability' in Parkinson's disease
Margaux F. Keller et al.
HUMAN MOLECULAR GENETICS (2012)
LRRK2 regulates mitochondrial dynamics and function through direct interaction with DLP1
Xinglong Wang et al.
HUMAN MOLECULAR GENETICS (2012)
α-Synuclein Controls Mitochondrial Calcium Homeostasis by Enhancing Endoplasmic Reticulum-Mitochondria Interactions
Tito Cali et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Leucine-rich repeat kinase 2 disturbs mitochondrial dynamics via Dynamin-like protein
Jingwen Niu et al.
JOURNAL OF NEUROCHEMISTRY (2012)
Potential role of α-synuclein in neurodegeneration: studies in a rat animal model
George Stoica et al.
JOURNAL OF NEUROCHEMISTRY (2012)
The link between the GBA gene and parkinsonism
Ellen Sidransky et al.
LANCET NEUROLOGY (2012)
LRRK2 knockout mice have an intact dopaminergic system but display alterations in exploratory and motor co-ordination behaviors
Kelly M. Hinkle et al.
MOLECULAR NEURODEGENERATION (2012)
Thalamic noradrenaline in Parkinson's disease: Deficits suggest role in motor and non-motor symptoms
Christian Pifl et al.
MOVEMENT DISORDERS (2012)
Mitochondrial transport in neurons: impact on synaptic homeostasis and neurodegeneration
Zu-Hang Sheng et al.
NATURE REVIEWS NEUROSCIENCE (2012)
Mechanisms underlying altered striatal synaptic plasticity in old A53T-α synuclein overexpressing mice
Alessandro Tozzi et al.
NEUROBIOLOGY OF AGING (2012)
ATP13A2 regulates mitochondrial bioenergetics through macroautophagy
Aaron M. Gusdon et al.
NEUROBIOLOGY OF DISEASE (2012)
ABERRANT STRIATAL SYNAPTIC PLASTICITY IN MONOGENIC PARKINSONISMS
G. Madeo et al.
NEUROSCIENCE (2012)
Striatal Dopamine Transmission Is Subtly Modified in Human A53Tα-Synuclein Overexpressing Mice
Nicola J. Platt et al.
PLOS ONE (2012)
Progressive dopaminergic cell loss with unilateral-to-bilateral progression in a genetic model of Parkinson disease
Maxime W. C. Rousseaux et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Impaired neurotransmission caused by overexpression of α-synuclein in nigral dopamine neurons
Martin Lundblad et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Genetics of Parkinson's Disease
Christine Klein et al.
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2012)
Acid β-Glucosidase Mutants Linked to Gaucher Disease, Parkinson Disease, and Lewy Body Dementia Alter α-Synuclein Processing
Valerie Cullen et al.
ANNALS OF NEUROLOGY (2011)
DJ-1 regulation of mitochondrial function and autophagy through oxidative stress
Melissa K. McCoy et al.
AUTOPHAGY (2011)
Parkinsonian Rotenone Mouse Model: Reevaluation of Long-Term Administration of Rotenone in C57BL/6 Mice
Masatoshi Inden et al.
BIOLOGICAL & PHARMACEUTICAL BULLETIN (2011)
PARIS (ZNF746) Repression of PGC-1α Contributes to Neurodegeneration in Parkinson's Disease
Joo-Ho Shin et al.
CELL (2011)
Gaucher Disease Glucocerebrosidase and α-Synuclein Form a Bidirectional Pathogenic Loop in Synucleinopathies
Joseph R. Mazzulli et al.
CELL (2011)
Rotenone, Paraquat, and Parkinson's Disease
Caroline M. Tanner et al.
ENVIRONMENTAL HEALTH PERSPECTIVES (2011)
DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy
Kelly Jean Thomas et al.
HUMAN MOLECULAR GENETICS (2011)
PARAQUAT- AND ROTENONE-INDUCED MODELS OF PARKINSON'S DISEASE
R. Nistico et al.
INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY (2011)
Depletion of PINK1 affects mitochondrial metabolism, calcium homeostasis and energy maintenance
Bavo Heeman et al.
JOURNAL OF CELL SCIENCE (2011)
The Parkinsonian Mimetic, MPP+, Specifically Impairs Mitochondrial Transport in Dopamine Axons
Jeong Sook Kim-Han et al.
JOURNAL OF NEUROSCIENCE (2011)
The antioxidant Trolox helps recovery from the familial Parkinson's disease-specific mitochondrial deficits caused by PINK1-and DJ-1-deficiency in dopaminergic neuronal cells
Jung Hee Shim et al.
MITOCHONDRION (2011)
Nonapoptotic Function of BAD and BAX in Long-Term Depression of Synaptic Transmission
Song Jiao et al.
NEURON (2011)
Chaperone-Mediated Autophagy Markers in Parkinson Disease Brains
Lydia Alvarez-Erviti et al.
ARCHIVES OF NEUROLOGY (2010)
Impaired in vivo dopamine release in parkin knockout mice
Genko Oyama et al.
BRAIN RESEARCH (2010)
Caspase-3 Activation via Mitochondria Is Required for Long-Term Depression and AMPA Receptor Internalization
Zheng Li et al.
CELL (2010)
Loss of the Parkinson's disease-linked gene DJ-1 perturbs mitochondrial dynamics
I. Irrcher et al.
HUMAN MOLECULAR GENETICS (2010)
PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy
Noriyuki Matsuda et al.
JOURNAL OF CELL BIOLOGY (2010)
α-Synuclein Transgenic Mice Reveal Compensatory Increases in Parkinson's Disease-Associated Proteins DJ-1 and Parkin and Have Enhanced α-Synuclein and PINK1 Levels After Rotenone Treatment
Sonia George et al.
JOURNAL OF MOLECULAR NEUROSCIENCE (2010)
Pathogenic Lysosomal Depletion in Parkinson's Disease
Benjamin Dehay et al.
JOURNAL OF NEUROSCIENCE (2010)
Distinct Levels of Dopamine Denervation Differentially Alter Striatal Synaptic Plasticity and NMDA Receptor Subunit Composition
Vincent Paille et al.
JOURNAL OF NEUROSCIENCE (2010)
Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1
Jaime N. Guzman et al.
NATURE (2010)
Impaired dopaminergic neurotransmission and microtubule-associated protein tau alterations in human LRRK2 transgenic mice
H. L. Melrose et al.
NEUROBIOLOGY OF DISEASE (2010)
Mitochondrial impairment in patients with Parkinson disease with the G2019S mutation in LRRK2
Heather Mortiboys et al.
NEUROLOGY (2010)
Progression of subtle motor signs in PINK1 mutation carriers with mild dopaminergic deficit
C. Eggers et al.
NEUROLOGY (2010)
Mitochondrial alpha-synuclein accumulation impairs complex I function in dopaminergic neurons and results in increased mitophagy in vivo
Shankar J. Chinta et al.
NEUROSCIENCE LETTERS (2010)
A53T-Alpha-Synuclein Overexpression Impairs Dopamine Signaling and Striatal Synaptic Plasticity in Old Mice
Alexander Kurz et al.
PLOS ONE (2010)
αβγ-Synuclein triple knockout mice reveal age-dependent neuronal dysfunction
Becket Greten-Harrison et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Endocytosis and clathrin-uncoating defects at synapses of auxilin knockout mice
Yang-In Yim et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Early synaptic pathophysiology in neurodegeneration: insights from Huntington's disease
Austen J. Milnerwood et al.
TRENDS IN NEUROSCIENCES (2010)
Pink1 Forms a Multiprotein Complex with Miro and Milton, Linking Pink1 Function to Mitochondrial Trafficking
Andreas Weihofen et al.
BIOCHEMISTRY (2009)
Enhanced sensitivity to group II mGlu receptor activation at corticostriatal synapses in mice lacking the familial parkinsonism-linked genes PINK1 or Parkin
G. Martella et al.
EXPERIMENTAL NEUROLOGY (2009)
Dopaminergic denervation and spine loss in the striatum of MPTP-treated monkeys
Rosa M. Villalba et al.
EXPERIMENTAL NEUROLOGY (2009)
Alpha-synuclein overexpression and aggregation exacerbates impairment of mitochondrial functions by augmenting oxidative stress in human neuroblastoma cells
Mordhwaj S. Parihar et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2009)
Impaired dopamine release and synaptic plasticity in the striatum of Parkin-/- mice
Tohru Kitada et al.
JOURNAL OF NEUROCHEMISTRY (2009)
Absence of nigral degeneration in aged parkin/DJ-1/PINK1 triple knockout mice
Tohru Kitada et al.
JOURNAL OF NEUROCHEMISTRY (2009)
Unexpected Lack of Hypersensitivity in LRRK2 Knock-Out Mice to MPTP (1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine)
Eva Andres-Mateos et al.
JOURNAL OF NEUROSCIENCE (2009)
Conditional transgenic mice expressing C-terminally truncated human α-synuclein (αSyn119) exhibit reduced striatal dopamine without loss of nigrostriatal pathway dopaminergic neurons
Joao Paulo L. Daher et al.
MOLECULAR NEURODEGENERATION (2009)
Mutant LRRK2R1441G BAC transgenic mice recapitulate cardinal features of Parkinson's disease
Yanping Li et al.
NATURE NEUROSCIENCE (2009)
A highly reproducible rotenone model of Parkinson's disease
Jason R. Cannon et al.
NEUROBIOLOGY OF DISEASE (2009)
Whole-genome conditional two-locus analysis identifies novel candidate genes for late-onset Parkinson's disease
A. Gonzalez-Perez et al.
NEUROGENETICS (2009)
Leucine-Rich Repeat Kinase 2 Regulates the Progression of Neuropathology Induced by Parkinson's-Disease-Related Mutant α-synuclein
Xian Lin et al.
NEURON (2009)
Parkinson Phenotype in Aged PINK1-Deficient Mice Is Accompanied by Progressive Mitochondrial Dysfunction in Absence of Neurodegeneration
Suzana Gispert et al.
PLOS ONE (2009)
R1441C mutation in LRRK2 impairs dopaminergic neurotransmission in mice
Youren Tong et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Genomic investigation of α-synuclein multiplication and parkinsonism
Owen A. Ross et al.
ANNALS OF NEUROLOGY (2008)
Reduction in memory in passive avoidance learning, exploratory behaviour and synaptic plasticity in mice with a spontaneous deletion in the ubiquitin C-terminal hydrolase L1 gene
Mikako Sakurai et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2008)
LRRK2 regulates synaptic vesicle endocytosis
Narae Shin et al.
EXPERIMENTAL CELL RESEARCH (2008)
Parkinson's disease: genetic versus toxin-induced rodent models
Muegen Terzioglu et al.
FEBS JOURNAL (2008)
PINK1 heterozygous rare variants: Prevalence, significance and phenotypic spectrum
Roberta Marongiu et al.
HUMAN MUTATION (2008)
Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
Derek Narendra et al.
JOURNAL OF CELL BIOLOGY (2008)
The function of mitochondria in presynaptic development at the neuromuscular junction
Chi Wai Lee et al.
MOLECULAR BIOLOGY OF THE CELL (2008)
Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study
Daniel G. Healy et al.
LANCET NEUROLOGY (2008)
Progressive behavioral deficits in DJ-1-deficient mice are associated with normal nigrostriatal function
Jayanth S. Chandran et al.
NEUROBIOLOGY OF DISEASE (2008)
DJ-1 is essential for long-term depression at hippocampal CA1 synapses
Yue Wang et al.
NEUROMOLECULAR MEDICINE (2008)
DJ-1 Modulates α-Synuclein Aggregation State in a Cellular Model of Oxidative Stress: Relevance for Parkinson's Disease and Involvement of HSP70
Sara Batelli et al.
PLOS ONE (2008)
Parkinson's disease and pesticides: a toxicological perspective
Jaime M. Hatcher et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2008)
The roles of kinases in familial Parkinson's disease
Mark R. Cookson et al.
JOURNAL OF NEUROSCIENCE (2007)
DJ-1 gene deletion reveals that DJ-1 is an atypical peroxiredoxin-like peroxidase
Eva Andres-Mateos et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Development of α-synuclein immunoreactive astrocytes in the forebrain parallels stages of intraneuronal pathology in sporadic Parkinson's disease
Heiko Braak et al.
ACTA NEUROPATHOLOGICA (2007)
Reduced vesicular storage of dopamine causes progressive nigrostriatal neurodegeneration
W. Michael Caudle et al.
JOURNAL OF NEUROSCIENCE (2007)
Impaired dopamine release and synaptic plasticity in the striatum of PINK1-deficient mice
Tohru Kitada et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Deciphering the role of heterozygous mutations in genes associated with parkinsonism
Christine Klein et al.
LANCET NEUROLOGY (2007)
DJ-1 and Parkin modulate dopamine-dependent behavior and inhibit MPTP-induced nigral dopamine neuron loss in mice FREE (vol 15, pg 698, 2007)
Jean-Charles Paterna et al.
MOLECULAR THERAPY (2007)
Dopamine-mediated regulation of corticostriatal synaptic plasticity
Paolo Calabresi et al.
TRENDS IN NEUROSCIENCES (2007)
Presynaptic α-synuclein aggregates, not Lewy bodies, cause neurodegeneration in dementia with Lewy bodies
Michael L. Kramer et al.
JOURNAL OF NEUROSCIENCE (2007)
PARK7 DJ-1 protects against degeneration of nigral dopaminergic neurons in Parkinson's disease rat model
Masatoshi Inden et al.
NEUROBIOLOGY OF DISEASE (2006)
High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease
A Bender et al.
NATURE GENETICS (2006)
Oxidative damage of DJ-1 is linked to sporadic Parkinson and Alzheimer diseases
J Choi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
LRRK2 expression linked to dopamine-innervated areas
D Galter et al.
ANNALS OF NEUROLOGY (2006)
LRRK2 is expressed in areas affected by Parkinson's disease in the adult mouse brain
J Simón-Sánchez et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2006)
Anatomical localization of Leucine-rich repeat kinase 2 in mouse brain
H Melrose et al.
NEUROSCIENCE (2006)
A comparison of degeneration in motor thalamus and cortex between progressive supranuclear palsy and Parkinson's disease
GM Halliday et al.
BRAIN (2005)
LRRK2 gene in Parkinson disease -: Mutation analysis and case control association study
C Paisán-Ruíz et al.
NEUROLOGY (2005)
A slowly developing dysfunction of dopaminergic nigrostriatal neurons induced by long-term paraquat administration in rats: an animal model of preclinical stages of Parkinson's disease?
K Ossowska et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2005)
ER retention and degradation as the molecular basis underlying Gaucher disease heterogeneity
I Ron et al.
HUMAN MOLECULAR GENETICS (2005)
The co-chaperone carboxyl terminus of Hsp70-interacting protein (CHIP) mediates α-synuclein degradation decisions between proteasomal and lysosomal pathways
YG Shin et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Redox cycling of the herbicide paraquat in microglial cultures
D Bonneh-Barkay et al.
MOLECULAR BRAIN RESEARCH (2005)
Nonlinear progression of Parkinson disease as determined by serial positron emission tomographic imaging of striatal fluorodopa F 18 activity
R Hilker et al.
ARCHIVES OF NEUROLOGY (2005)
Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial Parkinsonism-linked gene DJ-1
MS Goldberg et al.
NEURON (2005)
Parkin-deficient mice are not a robust model of parkinsonism
FA Perez et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Mitochondrial dysfunction and oxidative damage in parkin-deficient mice
JJ Palacino et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Comparison of kindreds with parkinsonism and α-synuclein genomic multiplications
M Farrer et al.
ANNALS OF NEUROLOGY (2004)
α-synuclein locus duplication as a cause of familial Parkinson's disease
MC Chartier-Harlin et al.
LANCET (2004)
PINK1 mutations are associated with sporadic early-onset parkinsonism
EM Valente et al.
ANNALS OF NEUROLOGY (2004)
Rotenone potentiates dopamine neuron loss in animals exposed to lipopolysaccharide prenatally
ZD Ling et al.
EXPERIMENTAL NEUROLOGY (2004)
Parkinsonism among Gaucher disease carriers
O Goker-Alpan et al.
JOURNAL OF MEDICAL GENETICS (2004)
Glucocerebrosidase mutations in subjects with parkinsonism
A Lwin et al.
MOLECULAR GENETICS AND METABOLISM (2004)
Mutations in LRRK2 cause autosomal-dominant Parkinsonism with pleomorphic pathology
A Zimprich et al.
NEURON (2004)
The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization
RM Canet-Avilés et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Axonal mitochondrial transport and potential are correlated
KE Miller et al.
JOURNAL OF CELL SCIENCE (2004)
Hereditary early-onset Parkinson's disease caused by mutations in PINK1
EM Valente et al.
SCIENCE (2004)
Classic toxin-induced animal models of Parkinson's disease: 6-OHDA and MPTP
A Schober
CELL AND TISSUE RESEARCH (2004)
Mechanism of toxicity in rotenone models of Parkinson's disease
TB Sherer et al.
JOURNAL OF NEUROSCIENCE (2003)
Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons
MS Goldberg et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
DJ-1 (PARK7), a novel gene for autosomal recessive, early onset parkinsonism
V Bonifati et al.
NEUROLOGICAL SCIENCES (2003)
Parkin gene inactivation alters behaviour and dopamine neurotransmission in the mouse
JM Itier et al.
HUMAN MOLECULAR GENETICS (2003)
Chronic systemic complex I inhibition induces a hypokinetic multisystem degeneration in rats
GU Höglinger et al.
JOURNAL OF NEUROCHEMISTRY (2003)
Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism
V Bonifati et al.
SCIENCE (2003)
Parkin protects against the toxicity associated with mutant α-synuclein:: Proteasome dysfunction selectively affects catecholaminergic neurons
L Petrucelli et al.
NEURON (2002)
Modeling Parkinsn's disease in rats: An evaluation of 6-OHDA lesions of the nigrostriatal pathway
R Deumens et al.
EXPERIMENTAL NEUROLOGY (2002)
Chronic systemic pesticide exposure reproduces features of Parkinson's disease
R Betarbet et al.
NATURE NEUROSCIENCE (2000)
Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity
Y Imai et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Oxidative damage linked to neurodegeneration by selective α-synuclein nitration in synucleinopathy lesions
BI Giasson et al.
SCIENCE (2000)
Association between early-onset Parkinson's disease and mutations in the parkin gene
CB Lücking et al.
NEW ENGLAND JOURNAL OF MEDICINE (2000)
Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system
A Abeliovich et al.
NEURON (2000)
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