4.6 Editorial Material

What should European nephrology do with the new CKD-EPI equation?

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Editorial Material Urology & Nephrology

Removal of race from estimation of kidney function

Bessie A. Young

Summary: Two studies suggest that cystatin-C-based equations can accurately estimate glomerular filtration rate regardless of race, addressing concerns about the incorrect use of race as a biological construct and its negative impact on health equity.

NATURE REVIEWS NEPHROLOGY (2022)

Article Urology & Nephrology

A Unifying Approach for GFR Estimation: Recommendations of the NKF-ASN Task Force on Reassessing the Inclusion of Race in Diagnosing Kidney Disease

Cynthia Delgado et al.

Summary: The National Kidney Foundation and the American Society of Nephrology have made recommendations regarding the consideration of race in GFR estimation. They suggest implementing the CKD-EPI creatinine equation without the race variable in all US laboratories and promoting the use of cystatin C for more accurate estimation. They also encourage research on new filtration markers and interventions to eliminate racial disparities. The unified approach should be adopted nationwide.

AMERICAN JOURNAL OF KIDNEY DISEASES (2022)

Article Urology & Nephrology

A New Panel-Estimated GFR, Including β2-Microglobulin and β-Trace Protein and Not Including Race, Developed in a Diverse Population

Lesley A. Inker et al.

Summary: The study suggests that GFR estimation using creatinine and cystatin C is more accurate but requires specification of race. Alternatively, using beta 2-microglobulin and beta-trace protein as filtration markers can reduce the influence of race and improve accuracy.

AMERICAN JOURNAL OF KIDNEY DISEASES (2021)

Article Urology & Nephrology

Availability and Affordability of Kidney Health Laboratory Tests around the Globe

Sri Lekha Tummalapalli et al.

Summary: The study revealed that kidney health laboratory tests are widely available globally, but there is significant variation in reimbursement values. Ensuring access to affordable diagnostic technology is crucial for mitigating the growth of kidney disease. The results are important for policymakers and researchers as countries develop strategies for kidney disease detection and management.

AMERICAN JOURNAL OF NEPHROLOGY (2021)

Article Medicine, General & Internal

Development and Validation of a Modified Full Age Spectrum Creatinine-Based Equation to Estimate Glomerular Filtration Rate A Cross-sectional Analysis of Pooled Data

Hans Pottel et al.

Summary: A new SCr-based equation, combining design features of the FAS and CKD-EPI equations, has been developed and validated to estimate glomerular filtration rate more accurately, especially during the transition from adolescence to adulthood. The equation shows low bias and fewer estimation errors across the full age spectrum.

ANNALS OF INTERNAL MEDICINE (2021)

Review Urology & Nephrology

The ⟪ race ⟫ correction in estimating glomerular filtration rate: an European point of view

Pierre Delanaye et al.

Summary: The ongoing debate about the race coefficient in the modification of diet for renal diseases and chronic kidney disease is centered on whether it is necessary for black individuals. Recent studies have shown that the race coefficient is inaccurate for European and African black populations, suggesting that it might be specific to black Americans. Criticism has arisen over the correction at the glomerular filtration rate level, with calls for dedicated studies in both Europe and the USA.

CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION (2021)

Article Medicine, General & Internal

Race, Genetic Ancestry, and Estimating Kidney Function in CKD

C. Hsu et al.

Summary: The study found that using serum creatinine levels to estimate GFR without taking race (or genetic ancestry) into account led to systematic misclassification. Estimating GFR with cystatin C produced similar results while eliminating negative consequences of race-based approaches.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Editorial Material Medicine, General & Internal

Time to Eliminate Health Care Disparities in the Estimation of Kidney Function

Winfred W. Williams et al.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Article Transplantation

Measured GFR: not a gold, but a gold-plated standard

Elise Boele-Schutte et al.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2017)

Article Medicine, General & Internal

Cystatin C versus Creatinine in Determining Risk Based on Kidney Function

Michael G. Shlipak et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

Article Medicine, General & Internal

Estimating Glomerular Filtration Rate from Serum Creatinine and Cystatin C

Lesley A. Inker et al.

NEW ENGLAND JOURNAL OF MEDICINE (2012)

Editorial Material Urology & Nephrology

The definition, classification, and prognosis of chronic kidney disease: a KDIGO Controversies Conference report

Andrew S. Levey et al.

KIDNEY INTERNATIONAL (2011)

Article Urology & Nephrology

Performance of the Cockcroft-Gault, MDRD, and New CKD-EPI Formulas in Relation to GFR, Age, and Body Size

Wieneke Marleen Michels et al.

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2010)

Article Medicine, General & Internal

A New Equation to Estimate Glomerular Filtration Rate

Andrew S. Levey et al.

ANNALS OF INTERNAL MEDICINE (2009)

Article Medical Laboratory Technology

Serum cystatin C is sensitive to small changes in thyroid function

P Wiesli et al.

CLINICA CHIMICA ACTA (2003)