Keeping immunostimulatory self-RNA under the rADAR

Structural modification of RNA by adenosine-to-inosine editing renders self-RNA invisible to RNA sensors of the innate immune system. Lack of RNA editing unleashes inflammatory responses that can lead to autoinflammation. A deeper understanding of the associated signalling pathways might reveal potential targets for drug discovery for autoinflammatory diseases.

Automated summary

Modified RNA, through adenosine-to-inosine editing, can avoid detection by RNA sensors in the innate immune system. Lack of RNA editing can trigger inflammatory responses and contribute to the development of autoinflammatory diseases. Understanding the signaling pathways involved may uncover potential targets for drug discovery.