ZAP70 holds the key to kinetic proofreading for TCR ligand discrimination

A key biochemical event that enables T cells to discriminate between TCR antigens of varying affinities and to respond only to high-affinity antigens is full activation of the kinase ZAP70.

Automated summary

Full activation of ZAP70 enables T cells to discriminate between TCR antigens of varying affinities and respond only to high-affinity antigens.