Two CTLA-4 ligands, separate pHates

The inhibitory checkpoint molecule CTLA-4 is essential for regulatory T cell function. A new study highlights the differential manner in which CTLA-4 binds CD80 and CD86, which determines its cellular fate and orchestrates immune tolerance regulation.

Automated summary

A new study reveals the differential binding manner of CTLA-4 to CD80 and CD86, which plays a crucial role in immune tolerance regulation.