Metabolic communication in the tumour-immune microenvironment

The metabolically hostile tumour microenvironment imposes barriers to tumour-infiltrating immune cells and impedes durable clinical remission following immunotherapy. Metabolic communication between cancer cells and their neighbouring immune cells could determine the amplitude and type of immune responses, highlighting a potential involvement of metabolic crosstalk in immune surveillance and escape. In this Review, we explore tumour-immune metabolic crosstalk and discuss potential nutrient-limiting strategies that favour anti-tumour immune responses.

Automated summary

The metabolically hostile tumour microenvironment can hinder immune cells and impede the effectiveness of immunotherapy. Metabolic communication between cancer cells and immune cells may play a crucial role in determining immune responses. Nutrient-limiting strategies may enhance anti-tumour immune responses.