Metabolic phosphatase moonlights for proteins

In tumours, cancer cells can overcome energy stress via differential regulation of non-canonical 'moonlighting' functions of metabolic enzymes. A study now shows that the metabolic phosphatase fructose-1,6-bisphosphatase 1 (FBP1) can act as a nuclear protein phosphatase and reveals how this process is inhibited in cancer cells.

Automated summary

A recent study reveals that the metabolic phosphatase fructose-1,6-bisphosphatase 1 (FBP1) can function as a nuclear protein phosphatase and explains its inhibition mechanism in cancer cells.