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Biochemistry & Molecular Biology
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Summary: Researchers have successfully generated synthetic whole embryo models with both embryonic and extraembryonic compartments using manipulated naive pluripotent stem cells. These models can complete embryonic development, develop organ progenitors, and exhibit complex structures similar to mouse embryos. This discovery highlights the potential of naive pluripotent cells.
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Multidisciplinary Sciences
Sergiu P. Pasca et al.
Summary: The nomenclature of human multicellular models of nervous system development and disease, including organoids, assembloids, and transplants, is clarified and provided as a basic framework to facilitate progress and improve communication with the scientific community and the public. These models derived from human pluripotent stem cells or primary tissue have the potential to provide insights into the unique development of the human nervous system and the progression and treatment of nervous system disorders.
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Multidisciplinary Sciences
Gianluca Amadei et al.
Summary: Researchers have successfully assembled stem cell-derived embryo models composed of embryonic stem cells, trophoblast stem cells, and extraembryonic endoderm stem cells, and demonstrated their ability to recapitulate the development of mouse embryos. This study provides a powerful tool for studying the roles of different cell lineages and genes in development.
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Cell Biology
Gianluca Amadei et al.
Summary: The study demonstrates that replacing XEN cells with ESCs transiently expressing Gata4 enhances the developmental potential of iETX embryos, enabling the study of anterior-posterior patterning and gastrulation in an in vitro system.
DEVELOPMENTAL CELL
(2021)
Article
Multidisciplinary Sciences
Alejandro Aguilera-Castrejon et al.
Summary: This study introduces a highly effective platform for ex utero culture of post-implantation mouse embryos, allowing embryos to develop from embryonic day 5.5 to hindlimb formation stage accurately. The system enables the introduction of various embryonic perturbations and micro-manipulations, facilitating the investigation of post-implantation morphogenesis in mammals.
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Cell & Tissue Engineering
Amander T. Clark et al.
Summary: Since the last revision in 2016, the ISSCR Guidelines for Stem Cell Research and Clinical Translation have seen rapid progress in research areas related to in vitro culture of human embryos, creation of stem cell-based embryo models, and in vitro gametogenesis. An international working group was convened to review the oversight process and provide an update to the guidelines, emphasizing on updating the categories of review and engagement with specialized scientific and ethical oversight process.
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Cell Biology
Yoko Ueda et al.
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Multidisciplinary Sciences
Go Nagamatsu et al.
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Fikri Birey et al.
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