期刊
NATURAL PRODUCT RESEARCH
卷 -, 期 -, 页码 -出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2022.2128346
关键词
Penicillium virgatum; endophytic fungus; cyclopentapeptide; antibacterial activities
资金
- National Natural Science Foundation of China [21762007]
- Guangxi Natural Science Foundation of China [2018GXNSFAA281169]
- State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Guangxi Normal University) [CMEMR2020-A]
A new cyclopentapeptide and seven known compounds were isolated from the endophytic fungus Penicillium virgatum GDGJ-227. The structure and configuration of the new cyclopentapeptide were determined using NMR, MS, and single-crystal X-ray diffraction analysis. Two compounds showed antibacterial activities.
One new cyclopentapeptide, cycloaspeptide H (1), featuring a serine residue, along with seven known compounds (2-8), was isolated from the endophytic fungus Penicillium virgatum GDGJ-227. The planar structure of 1 was elucidated by a comprehensive analysis of NMR and MS spectroscopic spectra, and the absolute configuration was determined by single-crystal X-ray diffraction (Cu K alpha) analysis. Compounds 7 and 8 displayed antibacterial activities against Bacillus subtilis and Enterobacter aerogenes with MIC values ranging from 12.5 to 50 mu g/mL. [GRAPHICS] .
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