期刊
NATURAL PRODUCT RESEARCH
卷 37, 期 17, 页码 2916-2923出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2022.2137502
关键词
Sauromatum giganteum; Parkinson's disease; phytochemicals; monoamine oxidase; molecular docking
The rhizome tuber of Sauromatum giganteum, known as 'Bai Fuzi' in China, contains various compounds that have inhibitory effects on MAO-B and protective effects on PC-12 cells. These findings suggest the potential of Sauromatum giganteum as an anti-Parkinson's disease herb.
The rhizome tuber of Sauromatum giganteum is known as 'Bai Fuzi' in China and has been ethnomedicinally used to treat various neurological diseases. It is considered to possess anti-Parkinson's disease (PD) potential, but the active compounds responsible for that is still unclear. In this work, nineteen compounds were isolated and identified from rhizome tuber of this plant, among which four were firstly reported, i.e. berberine (1), nicotinamide (2), rutin (3) and 5-caffeoylquinic acid (4). Six compounds (1, 3, 4, 8, 14 and 15) exhibited moderate inhibitory activity against MAO-B with IC50 of 118.8, 45.6, 96.2, 65.8, 40.0, and 49.8 mu M, and two compounds (3 and 4) displayed significant protective effect on 6-OHDA-induced PC-12 cell model. The molecular docking of the bioactive compounds and MAO-B was carried out to explore the binding mode. The findings revealed the potential of S. giganteum as anti-PD herb and its inclusion in TCM could be explored.
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