期刊
NATURAL PRODUCT RESEARCH
卷 -, 期 -, 页码 -出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2022.2128343
关键词
Acanthaceae; Thunbergia; napthoquinone; alpha-glucosidase; diabetes
资金
- Graduate School, Chulalongkorn University
- 90th Anniversary Chulalongkorn University Fund (Ratchadaphiseksomphot Endowment Fund)
- Ratchadaphiseksomphot Endowment Fund, Chulalongkorn University
A new compound named 5-acetoxyfuranonapthoquinone (1) was isolated from Thunbergia laurifolia L stems, along with nineteen known compounds (220). The structures of the isolated compounds were determined by spectroscopic analysis. The isolated compounds were evaluated for their inhibitory activity against alpha-glucosidase. Syringaresinol (7), rosmarinic acid (11), 1,2,8-trihydroxyxanthone (16), and isojacareubin (18) exhibited the most potent inhibitory activity. Kinetic study revealed that syringaresinol (7), 1,2,8-trihydroxyxanthone (16) and isojacareubin (18) inhibited maltase and sucrase activity in a non-competitive manner, while rosmarinic acid (11) showed non-competitive inhibition against maltase and mixed-mode inhibition against sucrase.
alpha-Glucosidase inhibitory assay-guided purification of Thunbergia laurifolia L stems yielded a new compound named 5-acetoxyfuranonapthoquinone (1) along with nineteen known compounds (220). The structures of the isolated compounds were elucidated by the analysis of multiple spectroscopic data. The isolated compounds were evaluated for alpha-glucosidase inhibition. Syringaresinol (7), rosmarinic acid (11), 1,2,8-trihydroxyxanthone (16), and isojacareubin (18) showed the most potent inhibitory activity among isolated compounds. Kinetic study indicated that syringaresinol (7), 1,2,8-trihydroxyxanthone (16) and isojacareubin (18) could inhibit maltase and sucrase function by non-competitive manner, and rosmarinic acid (11) was identified as a non-competitive inhibitor against maltase and a mixed-manner inhibitor against sucrase. [GRAPHICS] .
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